533-17-5

Basic information

• Product Name: 2'-Chloroacetanilide
• Synonyms: o-Chloracetanilide;o-Chloroacetanilide;2'-CHLOROACETANILIDE;2-CHLOROACETANILIDE;2-Chloroacetanilide, 98+%;2'-Chloroacetanilide, 99+%;AVO 2-Chloroacetanilide;Acetanilide, 2'-chloro- (8CI)
• CAS NO: 533-17-5
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.61
• EINECS: 208-555-2
• Product Categories: Anilines, Amides & Amines;Chlorine Compounds;Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 533-17-5.mol
• Article Data: 115

Chemical Properties

• Melting Point: 88-90 °C(lit.)
• Boiling Point: 306.5°C (rough estimate)
• Flash Point: 150.5 °C
• Appearance: beige to light brown crystalline powder
• Density: 1.1885 (rough estimate)
• Refractive Index: 1.5430 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.19±0.70(Predicted)
• Water Solubility: practically insoluble
• Merck: 14,2111
• BRN: 2086967
• CAS DataBase Reference: 2'-Chloroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Chloroacetanilide(533-17-5)
• EPA Substance Registry System: 2'-Chloroacetanilide(533-17-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 533-17-5(Hazardous Substances Data)

Usage

Chemical Properties

SLIGHTLY BEIGE CRYSTALLINE POWDER

Uses

2''-Chloroacetanilide

Upstream product

• 64-19-7 acetic acid 
• 95-51-2 o-chloroaniline 
• 79-43-6 dichloro-acetic acid 
• 579-11-3 N-chloroacetanilide 
• 108-90-7 chlorobenzene 
• 103-82-2 phenylacetic acid 
• 625-77-4 N-acetylacetamide 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 
• 103-84-4 Acetanilid 
• 2959-01-5 N,N'-dichloro-urea 
• 56-23-5 tetrachloromethane 
• 94-36-0 dibenzoyl peroxide 
• 4232-27-3 2,4-dinitrophenyl acetate 
• 91631-52-6 N-sulfonoxyacetanilide pyridinium salt 

Downstream Products

• 63720-79-6 3-(N-Ethyl-2-chloranilino)propionitril 
• 63720-70-7 3-(N-Acetyl-2-chloranilino)propionitril 
• 2103-49-3 N,N-dimethyl-N'-(2-chlorophenyl)formamidine 
• 42265-67-8 4-t-butyl-2-chloroaniline 
• 72487-80-0 N-(2-chloro-6-nitrophenyl)acetanilide 
• 121-87-9 2-Chloro-4-nitroaniline 
• 881-87-8 N-(2-chloro-4-nitrophenyl)acetamide 
• 56074-07-8 4-acetamido-3-chlorophenol 
• 6938-73-4 acetic acid-(2-chloro-5-trifluoromethyl-anilide) 
• 935742-43-1 N-(2-methylprop-2-enyl)-N-o-chlorophenylacetamide 
• 169214-12-4 [2'-²H]acetanilide 
• 68874-08-8 2-methyl-1-(4-methylphenyl)-1H-benzimidazole 

Relevant articles and documents

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Visible-light induced one-pot hydrogenation and amidation of nitroaromatics with carboxylic acids over 2D MXene-derived Pt/N-TiO2/Ti3C2

Pt nanoparticles supported on N doped titanium dioxide/titanium carbide (MXene) heterojunctions were employed as photocatalysts for the tandem reactions between aromatic nitro compounds and carboxylic acids to produce amide products. The 3%Pt/N-TiO2/Ti3C2 heterojunction was prepared by in situ grew TiO2 on Ti3C2 nanosheets and then N doped TiO2 with melamine, Pt nanoparticles with 3.3 nm mean diameter well dispersed on N-TiO2/Ti3C2. 3%Pt/N-TiO2/Ti3C2 had excellent amidation activity and chemoselectivity under visible-light irradiation. The elevated catalytic performance of 3%Pt/N-TiO2/Ti3C2 was owing to the improvement in photogenerated electron and hole separation efficiency through charge short-range directional transmission caused by the intimate contact between the TiO2 and the conductive Ti3C2. This direct hydrogenation along with amidation between nitroaromatics and carboxylic acids own actual merits in the amides produce with no harmful byproducts. In situ DRIFTS spectra verified that the amidation activation with visible light irradiation at 25 °C was much faster than heating.

Preparation and catalytic evaluation of a palladium catalyst deposited over modified clinoptilolite (Pd&at;MCP) for chemoselective N-formylation and N-acylation of amines

Novel palladium nanoparticles stabilized by clinoptilolite as a natural inexpensive zeolite prepared and used for N-formylation and N-acylation of amines at room temperature at environmentally benign reaction conditions in good to excellent yields. Pd (II) was immobilized on the surface of clinoptilolite via facile multi-step amine functionalization to obtain a sustainable, recoverable, and highly active nano-catalyst. The structural and morphological characterizations of the catalyst carried out using XRD, FT-IR, BET and TEM techniques. Moreover, the catalyst is easily recovered using simple filtration and reused for 7 consecutive runs without any loss in activity.