53336-12-2 Usage
Description
3,3'-Dipropylthiacarbocyanine Iodide, also known as DiSC3(5), is a fluorescent dye that is sensitive to changes in membrane potential. It is a carbocyanine dye with two propyl groups attached to the thiadicyanine core, which allows it to interact with biological membranes and respond to changes in their electrical potential. The fluorescence response of this dye to depolarization is dependent on the staining concentration and the detection method used.
Uses
Used in Cellular and Mitochondrial Membrane Potential Studies:
3,3'-Dipropylthiacarbocyanine Iodide is used as a fluorescent probe for monitoring changes in the cellular and mitochondrial membrane potential. It is particularly useful in studying the effects of various agents on the membrane potential of cells and mitochondria, which can provide insights into the mechanisms of action of these agents and their potential applications in various fields, such as pharmacology and toxicology.
Used in Biomedical Research:
In biomedical research, 3,3'-Dipropylthiacarbocyanine Iodide is used as a vital stain for assessing the membrane potential of cells, particularly in the context of cell viability and apoptosis. Its fluorescence properties allow for the visualization and quantification of membrane potential changes, which can be useful in understanding the effects of various treatments or conditions on cellular function.
Used in Drug Screening and Development:
3,3'-Dipropylthiacarbocyanine Iodide can be employed in drug screening and development as a tool to identify compounds that modulate membrane potential. By monitoring the fluorescence response of the dye to the presence of potential drug candidates, researchers can gain insights into the mechanisms of action of these compounds and their potential therapeutic applications.
Used in Analytical Techniques:
This dye can also be used in various analytical techniques, such as flow cytometry and fluorescence microscopy, to measure membrane potential in a high-throughput manner. These techniques allow for the rapid and accurate assessment of membrane potential changes in large populations of cells, which can be valuable in both research and clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 53336-12-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,3,3 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 53336-12:
(7*5)+(6*3)+(5*3)+(4*3)+(3*6)+(2*1)+(1*2)=102
102 % 10 = 2
So 53336-12-2 is a valid CAS Registry Number.
