53366-80-6

Basic information

• Product Name: 2-Butyn-1-one, 4,4-diethoxy-1-phenyl-
• CAS NO: 53366-80-6
• Molecular Formula: C14H16O3
• Molecular Weight: 232.279
• Mol File: 53366-80-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Butyn-1-one, 4,4-diethoxy-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butyn-1-one, 4,4-diethoxy-1-phenyl-(53366-80-6)
• EPA Substance Registry System: 2-Butyn-1-one, 4,4-diethoxy-1-phenyl-(53366-80-6)

Safety Data

• Hazardous Substances Data: 53366-80-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 81535-78-6 3,3-diethoxy-1-(tributylstannyl)prop-1-yne 
• 98-88-4 benzoyl chloride 
• 10160-87-9 Propiolaldehyde diethyl acetal 
• 53366-79-3 (+/-)-4-hydroxy-4-phenylbut-2-ynal diethyl acetal 

Downstream Products

• 1148158-67-1 5-(methoxycarbonyl)-4-phenylthiophene-2-carboxylic acid 
• 1400660-91-4 (S)-2-{[5-(3-Hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid 
• 1400661-94-0 5-[3-(tert-Butyl-dimethyl-silanyloxy)-benzylcarbamoyl]-3-phenyl-thiophene-2-carboxylic acid methyl ester 
• 1400661-95-1 5-(3-Hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carboxylic acid 
• 1400661-96-2 (S)-3-tert-Butoxycarbonylamino-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carbonyl]-amino}-propionic acid methyl ester 
• 1400661-98-4 (S)-3-Amino-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt 
• 1400662-00-1 (S)-2-{[5-(3-Hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid methyl ester 

Relevant articles and documents

THIAZOLE AND THIOPHENE COMPOUNDS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD

Palladium-Catalyzed Reactions of Acyl Chlorides with (1-Alkynyl)tributylstannanes. A Convenient Synthesis for 1-Alkynyl Ketones

Acyl chlorides couple with (1-alkynyl)tributylstannanes in the presence of catalytic amounts of palladium(II) or palladium(0) complexes to produce 1-alkynyl ketones in respectable yields.The couplings of isobutyryl, acetyl, benzoyl, and p-nitrobenzoyl chlorides with phenylethynyl-, (trimethylsilyl)ethynyl-, (carbomethoxy)ethynyl-, -1-propynyl>-, and (3,3-diethoxy-1-propynyl)tributylstannanes were investigated in the presence of tetrakis(triphenylphosphine)palladium(O), benzylchlorobis(triphenylphosphine)palladium(II), dichlorobis(triphenylphosphine)palladium(II), or phenyliodobis(triphenylphosphine)palladium(II).The reactions are highly selective in that only the alkynyl groups are transferred from the stannane.