53369-66-7

Basic information

• Product Name: 5-bromo-1-phenyl pyrimidine-2, 4 (1H, 3H)-dione
• Synonyms: 5-bromo-1-phenyl pyrimidine-2, 4 (1H, 3H)-dione
• CAS NO: 53369-66-7
• Molecular Weight: 267.082
• Mol File: 53369-66-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-bromo-1-phenyl pyrimidine-2, 4 (1H, 3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-1-phenyl pyrimidine-2, 4 (1H, 3H)-dione(53369-66-7)
• EPA Substance Registry System: 5-bromo-1-phenyl pyrimidine-2, 4 (1H, 3H)-dione(53369-66-7)

Safety Data

• Hazardous Substances Data: 53369-66-7(Hazardous Substances Data)

Upstream product

• 21321-07-3 1-phenyluracil 
• 15533-68-3 1-phenyldihydropyrimidine-2,4(1H,3H)-dione 
• 64-10-8 phenyl carbamate 
• 51-20-7 5-bromouracil 
• 108-90-7 chlorobenzene 

Downstream Products

• 352017-39-1 5-amino-1-phenylpyrimidine-2,4(1H,3H)-dione 
• 1357350-08-3 5-bromo-3-ethyl-1-phenyl-1H-pyrimidine-2,4-dione 
• 1357350-56-1 5-bromo-3-cyclopropylmethyl-1-phenyl-1H-pyrimidine-2,4-dione 
• 1358965-66-8 3-ethyl-5-(3-nitrophenyl)-1-phenyl-1H-pyrimidine-2,4-dione 
• 1357349-99-5 5-(3-chlorophenyl)-3-ethyl-1-phenyl-1H-pyrimidine-2,4-dione 
• 1357351-13-3 3-(3-ethyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)benzoic acid ethyl ester 

Relevant articles and documents

Solid-supported synthesis of N-alkylated derivatives of 5-bromo pyrimidine-2, 4-dione and Study of their cytotoxic effect

The presented study reports the synthesis of 5-bromo substituted pyrimidine-2,4-dione by conventional and solid-state microwave-assisted methodology. 5-bromo pyrimidine-2,4-dione derivatives represent the novel group of compounds possessing remarkable anti-tumor and antibacterial activities with significant therapeutic effects such as anti-neoplastic as well. Thus, a diversity-oriented convergent synthesis of complex organic molecules from simple and readily available substrates has been carried out that has resulted in the derivatization of 5-bromo pyrimidine-2,4 dione predominately giving N1 and N3 substituted compounds where R may be the alkyl, aryl, cyclohexyl methyl etc. In addition, use of solid-state microwave-assisted protocol proved to be of vital importance in terms of energy efficiency and designing a solvent-free ecofriendly synthetic route with considerably reduced reaction time.

Selective Oxidative Halogenation of Uracils

A variety of N-substituted uracils has been selectively brominated to the corresponding 5-bromouracils in high yield by CHBr3-O2.Both oxidative bromination and chlorination of N-substituted uracils can be performed by means of combination of haloalkane solvents with m-chloroperbenzoic acid, magnesium monoperoxyphthalate, tert-butyl hydroperoxide or iodosylbenzene.Intermediates along the reaction path leading to the 5-halouracils have been identified; the intermediates depend on the oxidant used.Mechanistic aspects of the halogenation reactions and the reactive intermediates are discussed.

Pyrimidine derivatives and related compounds. XIX. Synthesis and analgetic and antiinflammatory activities of 1,3 substituted 5 dimethylaminouracil derivatives

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