5337-94-0

Basic information

• Product Name: 5-bromo-2,2-dimethyl-2,3-dihydro-1-benzofuran
• CAS NO: 5337-94-0
• Molecular Formula: C₁₀H₁₁BrO
• Molecular Weight: 227.0977
• Mol File: 5337-94-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 258.9°C at 760 mmHg
• Flash Point: 102.5°C
• Density: 1.383g/cm³
• Vapor Pressure: 0.0216mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 5-bromo-2,2-dimethyl-2,3-dihydro-1-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2,2-dimethyl-2,3-dihydro-1-benzofuran(5337-94-0)
• EPA Substance Registry System: 5-bromo-2,2-dimethyl-2,3-dihydro-1-benzofuran(5337-94-0)

Safety Data

• Hazardous Substances Data: 5337-94-0(Hazardous Substances Data)

Upstream product

• 5820-27-9 1-(2’-methylallyloxy)-4-bromobenzene 
• 106-41-2 4-bromo-phenol 
• 1165738-86-2 4-bromo-2-(2’-methylallyl)phenol 
• 6337-33-3 2,2-dimethyl-2,3-dihydro-1-benzofuran 

Downstream Products

• 903556-72-9 C₁₁H₁₁NO 
• 38002-92-5 2,3-dihydro-2,2-dimethylbenzofuran-5-carboxaldehyde 

Relevant articles and documents

LXR MODULATORS

The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.

Lewis-acid-promoted arylation reaction: Synthesis of dihydrobenzofuran derivatives from aryltriazenes

A Lewis-acid-promoted approach to the synthesis of highly functionalized dihydrobenzofuran derivatives was developed. A diverse range of functional groups are tolerated in this type of reaction. The reaction mechanism investigation indicates that the highly reactive phenyl cation intermediate is probably involved in this process. The chirality of substrate is retained under the reaction conditions.

N-phenpropylcuclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase

The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alkoxy, —NR2 R3 or —NR4SO2R5; X is the linkage —(CH2)n— or —(CH2)q—O— (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxy(C1-3alkyl); C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.