53370-50-6

Basic information

• Product Name: 3,N-DIHYDROXY-PROPIONAMIDINE
• Synonyms: 3,N-DIHYDROXY-PROPIONAMIDINE;(Z)-N',3-dihydroxypropanimidamide
• CAS NO: 53370-50-6
• Molecular Formula: C₃H₈N₂O₂
• Molecular Weight: 104.11
• Product Categories: pharmacetical
• Mol File: 53370-50-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 92-94 °C
• Boiling Point: 245.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 14.17±0.10(Predicted)
• CAS DataBase Reference: 3,N-DIHYDROXY-PROPIONAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,N-DIHYDROXY-PROPIONAMIDINE(53370-50-6)
• EPA Substance Registry System: 3,N-DIHYDROXY-PROPIONAMIDINE(53370-50-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 53370-50-6(Hazardous Substances Data)

Usage

Description

3,N-Dihydroxy-propionamidine, also known as DHPA, is a chemical compound with the molecular formula C3H8N2O3. It is a derivative of propionamidine and exists as a white to off-white powder. DHPA is primarily used as a pharmaceutical intermediate in the synthesis of various drugs, including antiviral and antifungal agents. It is also known for its potential antimicrobial properties and has been studied for its ability to inhibit the growth of certain bacteria and fungi. Additionally, DHPA has been investigated for its potential use in the treatment of various medical conditions, but further research is needed to fully understand its therapeutic potential and mechanisms of action.

Uses

Used in Pharmaceutical Industry:
3,N-Dihydroxy-propionamidine is used as a pharmaceutical intermediate for the synthesis of various drugs, including antiviral and antifungal agents. Its unique chemical structure allows it to be a key component in the development of new medications.
Used in Antimicrobial Applications:
3,N-Dihydroxy-propionamidine is used as an antimicrobial agent for its potential to inhibit the growth of certain bacteria and fungi. Its ability to target and disrupt microbial cells makes it a valuable compound in the fight against infectious diseases.
Used in Medical Research:
3,N-Dihydroxy-propionamidine is used in medical research for its potential therapeutic applications in treating various medical conditions. Further studies are needed to explore its full potential and understand its mechanisms of action in the human body.

Upstream product

• 109-78-4 3-Hydroxypropionitrile 

Downstream Products

• 166262-31-3 3-(2'-hydroxyethyl)-5-phenyl-1,2,4-oxadiazole 
• 1254974-84-9 C₂₇H₃₁N₅O₅ 
• 796119-08-9 2-{5-[3-chloro-5-(3,3-dichloro-allyloxy)-2-methoxy-phenyl]-[1,2,4]oxadiazol-3-yl}-ethanol 

Relevant articles and documents

Scalable and Safe Transformation of 3-Hydroxypropionitrile to Its Amidoxime

Scalable synthesis of amidoxime 1 by nucleophilic addition of 50% aq. NH2OH to 3-hydroxypropionitrile is reported. In the presence of hydroxyl and amidoxime moieties, this dually functional compound can be manipulated for the synthesis of heterocyclic compounds that may be useful for the energetic materials and pharmaceutical chemistry communities. In preparing 1, it was discovered that previously published procedures were either irreproducible and/or the processes were not practical on larger scales. Previously published procedures required flash chromatography and/or afforded the amidoxime product in a low yield. The improved method discussed in this paper involves rotary evaporation of the completed reaction mixture to remove excess water, followed by trituration in acetone to obtain 83–90% yields. This method has been carried out multiple times on the 86–94 g scale, with minimal exothermic activity detected.

Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4- methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases

Class I phosphoinositide 3-kinases (PI3Ks), particularly PI3Kγ, have become attractive drug targets for inflammatory and autoimmune disorders such as rheumatoid arthritis. Herein, we describe the synthesis and the structure-activity relationships (SAR) of a series of 2-amino-5-oxadiazolyl thiazoles, culminating in the identification of 8j (TASP0415914), an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TASP0415914 demonstrated good potency in a cell-based assay and, furthermore, exhibited in vivo efficacy in a collagen induced arthritis (CIA) model in mice after oral administration.

NOVEL NITRILE AND AMIDOXIME COMPOUNDS AND METHODS OF PREPARATION

The present application relates to semiconductor processing compositions comprising at least one compound containing at least one amidoxime functional group and to methods of using these compositions in semiconductor processing. The present application also describes the preparation of amidoximes for a semiconductor processing composition by (a) mixing a cyanoethylation catalyst, a nucleophile and an alpha-unsaturated nitrile to produce a cyanoethylation product; and (b) converting a cyano group in the cyanoethylation product into an amidoxime functional group.