53391-42-7Relevant articles and documents
Synthesis of distamycin a polyamides targeting G-quadruplex DNA
Moore, Michael J. B.,Cuenca, Francisco,Searcey, Mark,Neidle, Stephen
, p. 3479 - 3488 (2006)
A number of amide-linked oligopyrroles based on distamycin molecules have been synthesized by solid-state methods, and their interactions with a human intramolecular G-quadruplex have been measured by a melting procedure. Several of these molecules show an enhanced ratio of quadruplex vs. duplex DNA binding compared to distamycin itself, including one with a 2,5-disubstituted pyrrole group. Quadruplex affinity increases with the number of pyrrole groups, and it is suggested that this is consistent with a mixed groove/G-quartet stacking binding mode. The Royal Society of Chemistry 2006.