53400-41-2

Basic information

• Product Name: 5,6,7,8-TETRAHYDROQUINOLINONE-5
• Synonyms: 5,6,7,8-TETRAHYDROQUINOLINONE-5;5,6,7,8-TETRAHYDRO-5-QUINOLINONE;7,8-DIHYDRO-6H-QUINOLIN-5-ONE;7,8-dihydroquinolin-5(6H)-one;5(6H)-Quinolinone, 7,8-dihydro-;5,6,7,8-Tetrahydroquinolin-5-one;7,8-Dihydroquinoline-5(6H)-one;7,8-dihydro-5(6H)-Quinoli...
• CAS NO: 53400-41-2
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Product Categories: pharmacetical;Quinoline Derivertives
• Mol File: 53400-41-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 269.3 °C at 760 mmHg
• Flash Point: 123.8 °C
• Appearance: /
• Density: 1.168 g/cm³
• Vapor Pressure: 0.00731mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.85±0.20(Predicted)
• CAS DataBase Reference: 5,6,7,8-TETRAHYDROQUINOLINONE-5(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-TETRAHYDROQUINOLINONE-5(53400-41-2)
• EPA Substance Registry System: 5,6,7,8-TETRAHYDROQUINOLINONE-5(53400-41-2)

Safety Data

• Hazardous Substances Data: 53400-41-2(Hazardous Substances Data)

Usage

Description

5,6,7,8-TETRAHYDROQUINOLINONE-5 is a chemical compound with the molecular formula C9H11NO2. It is an organic compound that belongs to the quinolone family, which are known for their diverse range of biological activities and applications in various fields.

Uses

Used in Pharmaceutical Industry:
5,6,7,8-TETRAHYDROQUINOLINONE-5 is used as a reagent for the synthesis of pyridino N-alkylated nicotine analogs, which can serve as nicotinic acetylcholine receptor antagonists. These antagonists have potential applications in the treatment of various neurological disorders and conditions related to nicotine addiction.
Used in Organic Synthesis:
In the field of organic chemistry, 5,6,7,8-TETRAHYDROQUINOLINONE-5 is used in the total synthesis of (±)-tangutorine, a novel indole alkaloid. 5,6,7,8-TETRAHYDROQUINOLINONE-5 has potential applications in the development of new drugs and therapeutic agents due to its unique chemical structure and properties.

InChI:InChI=1/C9H9NO/c11-9-5-1-4-8-7(9)3-2-6-10-8/h2-3,6H,1,4-5H2

Upstream product

• 22971-46-6 5-oxo-5-(pyridin-3-yl)pentanoic acid 
• 87549-96-0 1-(pyridin-3-yl)cyclobutanol 

Downstream Products

• 155277-64-8 1-(4-chlorophenyl)-8,9-dihydro-7H-pyrrolo[3,2,1-ij]quinolin-7-one 
• 155277-63-7 1-(4-bromophenyl)-8,9-dihydro-7H-pyrrolo[3,2,1-ij]quinolin-7-one 
• 35135-35-4 3a-(3,4-dimethoxy-phenyl)-1-methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-f]quinoline 
• 29365-71-7 (+)-<5S>-5-hydroxy-5,6,7,8-tetrahydroquinoline 
• 150737-70-5 (R)-5,6,7,8-tetrahydroquinolin-5-ol 
• 1392299-49-8 7-phenyl-9-(pyrrolidin-1-yl)-5,6-dihydrobenzo[f]quinoline-10-carbonitrile 
• 1392299-48-7 7-phenyl-9-(piperidin-1-yl)-5,6-dihydrobenzo[f]quinoline-10-carbonitrile 

Relevant articles and documents

Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chemistry.

Tandem Oxidative Ring-Opening/Cyclization Reaction in Seconds in Open Atmosphere for the Synthesis of 1-Tetralones in Water-Acetonitrile

A mild and practical tandem oxidative ring-opening/cyclization reaction mediated by Ce4+ for the synthesis of 1-tetralones is presented. This rapid transformation was completed within 30 s and conducted in an open reactor at 0 °C in a water-acetonitrile mixture. Various cyclobutanol derivatives are transformed into desired products in good to high yields, and this reaction can be easily scaled up to the gram scale.

Cyclopenteno[b]pyridine derivatives

The invention relates to novel cyclopenteno[b]pyridine derivatives which have a group X on the 7-position and related tricyclic compounds. X is CONHR3, or CO2 R5 wherein R3 is hydrogen or lower alkyl and R5 is hydrogen or a lower alkyl or lower aralkyl group which may be substituted by alkyl, alkoxy, halogen, nitro or trifluoromethyl; other substituents may be present. The compounds are intermediates for compounds wherein X is CSNHR3 which are anti-ulcer agents.