53403-04-6

Basic information

• Product Name: (+)-(1S,2S)-1-methyl-2-phenylcyclopropane
• Synonyms: (+)-(1S,2S)-1-methyl-2-phenylcyclopropane
• CAS NO: 53403-04-6
• Molecular Weight: 132.205
• Mol File: 53403-04-6.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: (+)-(1S,2S)-1-methyl-2-phenylcyclopropane(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(1S,2S)-1-methyl-2-phenylcyclopropane(53403-04-6)
• EPA Substance Registry System: (+)-(1S,2S)-1-methyl-2-phenylcyclopropane(53403-04-6)

Safety Data

• Hazardous Substances Data: 53403-04-6(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 1117-96-0 Diazoethan 
• 34008-94-1 tert-butyl ethyl sulfone 
• 187737-37-7 propene 
• 637-50-3 1-phenylpropene 
• 75-11-6 diiodomethane 
• 75-07-0 acetaldehyde 
• 766-90-5 cis-1-phenyl-1-propylene 
• 873-66-5 1-propenylbenzene 
• 593-71-5 Chloroiodomethane 
• 5682-61-1 (1S,2S)-2-phenylcyclopropanecarboxylic acid methyl ester 
• 110659-58-0 (1S,2S)-trans-1-(hydroxymethyl)-2-phenylcyclopropane 
• 97-71-2 ethyl (S,S)-2-phenylcyclopropane-1-carboxylate 
• 23020-15-7 (1S,2S)-2-phenylcyclopropane-1-carboxylic acid 

Downstream Products

• 26278-68-2 1,3-dimethoxy-1-phenylbutane 
• 874016-73-6 (1S,2R)-3-(2-methyl-1-cyclopropyl)-cyclohexa-3,5-diene-1,2-diol 
• 127379-92-4 (1S,2R)-2-methyl-1-phenyl-propane-1,3-diol 
• 7087-77-6 (1S,2S)-2-methyl-1-phenyl-propane-1,3-diol 
• 538-93-2 1-phenyl-2-methylpropane 
• 104-51-8 1-butylbenzene 
• 103-79-7 1-phenyl-acetone 
• 80735-94-0 1-Phenyl-3-buten-1-ol 
• 110659-58-0 (1S,2S)-trans-1-(hydroxymethyl)-2-phenylcyclopropane 
• 137601-78-6 p-(cis-2-Methylcyclopropyl)-α-methylbenzyl Chloride 
• 137601-88-8 p-(cis-2-Methylcyclopropyl)-α-methylbenzyl Alcohol 
• 137601-78-6 p-(trans-2-Methylcyclopropyl)-α-methylbenzyl Chloride 
• 137601-88-8 p-(trans-2-Methylcyclopropyl)-α-methylbenzyl Alcohol 
• 110659-49-9 (+)-(1'S,2'S)-2-(2'-methylcyclopropyl)aniline 

Relevant articles and documents

Lewis Base-Promoted Ring-Opening 1,3-Dioxygenation of Unactivated Cyclopropanes Using a Hypervalent Iodine Reagent

A facile and effective system has been developed for the regio- and chemoselective ring-opening/electrophilic functionalization of cyclopropanes through C?C bond activation by [bis(trifluoroacetoxy)iodo]benzene with the aid of the Lewis basic promoter p-toluenesulfonamide. The p-toluenesulfonamide-promoted system works well for a wide range of cyclopropanes, resulting in the formation of 1,3-diol products in good yields and regioselectivity.

Cyclopropanation of alkenes with CH2I2/Et3Al by the phase-vanishing method based on fluorous phase screen

Phase-vanishing (PV) method using perfluorohexanes as a screen phase was applied to cyclopropanation reactions with CH2I2/Et2Zn and CH2I2/Et3Al. When Et3Al was used as a carbenoid generator, the reaction proceeded smoothly and desired cyclopropane derivatives were obtained in high yield. The PV cyclopropanation took 2 or 3 days to complete, however, reduction of reaction time by a factor of 2-3 was also achieved by vigorous stirring after the bottom CH2I2 layer disappeared.

Processing of cyclopropylarenes by toluene dioxygenase: Isolation and absolute configuration of metabolites

Several arenes possessing a cyclopropyl substituent were subjected to enzymatic oxidation with toluene dioxygenase. The absolute configuration of metabolites was established by chemical means.