53406-00-1Relevant articles and documents
OPTIMIZATION OF THE REACTION CONDITIONS USING A NADH MODEL GRAFTED ON A MERRIFIELD TYPE RESIN
Dupas, G.,Decormeille, A.,Bourguignon, J.,Queguiner, G.
, p. 2579 - 2590 (1989)
The synthesis of reducing agent 3, 1,4-dihydronicotinamide grafted on a Merrifield resin, is described.The reaction conditions of reagent 3 are optimized, with respect to the solvent and the catalyst amount.The reagent 3 is more sensitive to traces of wat
Efficient Synthesis of Nicotinamide-1-15N for Ultrafast NMR Hyperpolarization Using Parahydrogen
Shchepin, Roman V.,Barskiy, Danila A.,Mikhaylov, Dmitry M.,Chekmenev, Eduard Y.
, p. 878 - 882 (2016)
Nicotinamide (a vitamin B3 amide) is one of the key vitamins as well as a drug for treatment of M. tuberculosis, HIV, cancer, and other diseases. Here, an improved Zincke reaction methodology is presented allowing for straightforward and scalab
D-amino acid-based NAD analogue, synthesis and application thereof
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Paragraph 0028-0029, (2020/06/20)
The invention discloses a nicotinamide adenine dinucleotide (NAD) analogue based on D-amino acid, a synthesis method and application thereof, wherein the structural general formula of the D-amino acid-based NAD analogue is defined in the specificati
Enhanced Ene-Reductase Activity through Alteration of Artificial Nicotinamide Cofactor Substituents
L?w, Sebastian A.,L?w, Isabell M.,Weissenborn, Martin J.,Hauer, Bernhard
, p. 911 - 915 (2016/03/15)
The reduction of activated C=C double bonds is an important reaction in synthetic chemistry owing to the potential formation of up to two new stereogenic centers. Artificial nicotinamide cofactors were recently presented as alternative suppliers of hydride equivalents needed for alkene reduction. To study the effect of cofactors on the reduction of activated alkenes, a set of N-substituted synthetic nicotinamide cofactors with differing oxidation potentials were synthesized and their electrochemical and kinetic behavior was studied. The effects of the synthetic cofactors on enzyme activity of four ene reductases are outlined in this study, where the cofactor mimic with an N-substituted 4-hydroxy-phenyl residue led to a sixfold higher vmax relative to the natural cofactor NADH. Artificial nicotinamide cofactor substituents: A set of N-substituted synthetic nicotinamide cofactors with differing oxidation potentials were synthesized and their electrochemical and kinetic behavior was studied. The effects of the synthesized cofactors on the enzyme activity of four ene reductases are outlined. The cofactor mimic with an N-substituted 4-hydroxy-phenyl residue led to a sixfold higher vmax relative to the natural cofactor NADH.
