5343-54-4

Basic information

• Product Name: 2,2-DIMETHYLDECANOIC ACID
• Synonyms: 2,2-DIMETHYLDECANOIC ACID;2,2-dimethylcapric acid
• CAS NO: 5343-54-4
• Molecular Formula: C₁₂H₂₄O₂
• Molecular Weight: 200.32
• Mol File: 5343-54-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 293.36°C (estimate)
• Flash Point: 137.3°C
• Appearance: /
• Density: 0.8910 (rough estimate)
• Vapor Pressure: 0.000252mmHg at 25°C
• Refractive Index: 1.4235 (estimate)
• PKA: 4.86±0.45(Predicted)
• CAS DataBase Reference: 2,2-DIMETHYLDECANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYLDECANOIC ACID(5343-54-4)
• EPA Substance Registry System: 2,2-DIMETHYLDECANOIC ACID(5343-54-4)

Safety Data

• Hazardous Substances Data: 5343-54-4(Hazardous Substances Data)

Usage

General Description

2,2-DIMETHYLDECANOIC ACID, also known as diisobutylketene, is a carboxylic acid with a chemical formula of C12H24O2. It is a clear, colorless liquid with a faint odor that is commonly used in the production of chemicals and pharmaceuticals. 2,2-DIMETHYLDECANOIC ACID is also used as an intermediate in the synthesis of plasticizers, lubricants, and surfactants. It is considered to be non-toxic and non-irritating, with low potential for bioaccumulation and a low volatility. 2,2-DIMETHYLDECANOIC ACID is primarily used as a building block in the manufacturing of various chemical products and does not pose significant risks to human health or the environment when used properly.

InChI:InChI=1/C12H24O2/c1-4-5-6-7-8-9-10-12(2,3)11(13)14/h4-10H2,1-3H3,(H,13,14)

Upstream product

• 74-83-9 methyl bromide 
• 24323-23-7 2-methyl decanoic acid 
• 111-83-1 1-bromo-octane 
• 79-31-2 isobutyric Acid 
• 61415-93-8 2,2-dimethyldecanenitrile 
• 108753-59-9 isobutyric acid-(1,1-diethyl-propyl ester) 
• 855756-24-0 2,2-dimethyl-decanoic acid amide 

Downstream Products

• 117815-03-9 4,4-dimethyl-2-[2-methyldecan-2-yl]-4,5-dihydrooxazole 
• 140112-69-2 2,2-Dimethyl-decanoic acid (2,4,6-trimethoxy-phenyl)-amide 

Relevant articles and documents

CYCLOALKYL-CONTAINING CARBOXYLIC ACIDS AND USES THEREOF

The present application discloses a compound of formula (I) or a salt thereof: (I) and compositions comprising such compound or salt thereof. The use of such compound, salt thereof or composition comprising same for treating anemia or leukopenia, fibrosis, cancer, hypertension and/or a metabolic condition in a subject is also disclosed.

Inhibitors of Acyl-CoA:cholesterol acyltransferase. I. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents

A series of fatty acid anilides was prepared, and compounds were tested for their ability to inhibit the enzyme acyl-CoA:cholesterol acyltransferase (ACAT) in vitro and to lower plasma total cholesterol and elevate high- density lipoprotein cholesterol in cholesterol-fed rats in vivo. The compounds reported were found to fall into two subclasses with different anilide SAR. For nonbranched acyl analogues, inhibitory potency was found to be optimal with bulky 2,6-dialkyl substitution. For α-substituted acyl analogues, there was little dependence of in vitro potency on anilide substitution and 2,4,6-trimethoxy was uniquely preferred. Most of the potent inhibitors (IC50 50 nM) were found to produce significant reductions in plasma total cholesterol in cholesterol-fed rats. Additionally, in vivo activity could be improved significantly by the introduction of α,α- disubstitution into the fatty acid portion of the molecule. A narrow group of α,α-disubstituted trimethoxyanilides, exemplified by 2,2-dimethyl-N-(2,4,6- trimethoxyphenyl)dodecanamide (39), was found to not only lower plasma total cholesterol (-60%) in cholesterol-fed rats but also elevate levels of high- density lipoprotein cholesterol (+94%) in this model at the screening dose of 0.05% in the diet (ca. 50 mg/kg).