5343-64-6Relevant articles and documents
Design, synthesis, in vitro antiproliferative evaluation and in silico studies of new VEGFR-2 inhibitors based on 4-piperazinylquinolin-2(1H)-one scaffold
Hassan, Abdelfattah,Badr, Mohamed,Abdelhamid, Dalia,Hassan, Heba A.,Abourehab, Mohammed A.S.,Abuo‐Rahma, Gamal El‐Din A.
, (2022/01/31)
Angiogenesis is essential in the growth of solid tumors which need oxygen and nutrients supply to grow in size. The VEGF/VEGFR-2 signaling pathway plays an important role in tumor angiogenesis. Sorafenib is an FDA approved cancer therapeutic with activity
Facile synthesis, antimicrobial evaluation and molecular docking studies of pyrazole-imidazole-triazole hybrids
Deswal, Laxmi,Kumar, Ashwani,Kumar, Devinder,Punia, Suman,Verma, Vikas
, (2020/09/18)
A series of eighteen pyrazole-imidazole-triazole hybrid (2-(4-((2-(substituted-1H-pyrazol-1-yl)-4-phenyl-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(substituted)phenylacetami- de) (6a-6r) are synthesized through click reaction between in situ gener
Synthesis and evaluation of novel pyrazole-imidazole hybrids as antimicrobial candidates
Punia, Suman,Verma, Vikas,Kumar, Devinder,Kumar, Ashwani,Deswal, Laxmi,Parshad, Mahavir
, p. 2832 - 2846 (2021/07/26)
The present study describes a facile and efficient synthesis of 1-(N-arylacetamide)-4-phenyl-2-pyrazolyl-imidazole 7a–7t by reacting 1-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole (3a)/3,5-dimethyl-1-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole (3b) with 2-bromo-N-