5344-44-5

Basic information

• Product Name: 3-chloro-5-nitro-aniline
• Synonyms: 3-chloro-5-nitro-aniline
• CAS NO: 5344-44-5
• Molecular Formula: C₆H₅ClN₂O₂
• Molecular Weight: 172.57
• Mol File: 5344-44-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 332.7°Cat760mmHg
• Flash Point: 155°C
• Appearance: /
• Density: 1.494g/cm³
• Vapor Pressure: 0.000144mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 3-chloro-5-nitro-aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-5-nitro-aniline(5344-44-5)
• EPA Substance Registry System: 3-chloro-5-nitro-aniline(5344-44-5)

Safety Data

• Hazardous Substances Data: 5344-44-5(Hazardous Substances Data)

Usage

General Description

3-Chloro-5-nitro-aniline is a chemical compound with the molecular formula C6H5ClN2O2. It is a pale yellow crystalline solid that is soluble in organic solvents. 3-Chloro-5-nitro-aniline is primarily used as an intermediate in the synthesis of various pharmaceuticals, pesticides, and dyes. It is also utilized as a reagent in organic synthesis and as a starting material for the production of other chemical compounds. Due to its potential toxicity, 3-chloro-5-nitro-aniline should be handled and stored with precautions, and its use should comply with safety regulations and guidelines.

InChI:InChI=1/C6H5ClN2O2/c7-4-1-5(8)3-6(2-4)9(10)11/h1-3H,8H2

Upstream product

• 618-86-0 1-chloro-3,5-dinitrobenzene 
• 64-17-5 ethanol 
• 7783-06-4 hydrogen sulfide 
• 7664-41-7 ammonia 
• 618-87-1 3, 5-dinitroaniline 
• 99-65-0 meta-dinitrobenzene 

Downstream Products

• 618-62-2 3,5-dichloro-1-nitrobenzene 
• 5540-64-7 Nonanoic acid (3-chloro-5-nitro-phenyl)-amide 
• 60498-65-9 N-Methyl-N-p-toluolsulfonyl-3-chlor-5-nitroanilin 
• 185500-57-6 1-Chloro-3-isothiocyanato-5-nitro-benzene 
• 185500-54-3 1-tert-Butyl-3-(3-chloro-5-nitro-phenyl)-thiourea 
• 107707-33-5 N-[3,5-dichlorophenyl]thiourea 
• 626-43-7 3,5-Dichloroaniline 
• 6590-93-8 3,5-dichlorophenylisothiocyanate 
• 1309831-79-5 1-(3-Chloro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one 
• 1261790-98-0 C₇H₃ClN₂O₃ 
• 1309831-78-4 1-(3-Chloro-5-nitrophenyl)-1H-tetrazol-5(4H)-one 
• 1309831-81-9 1-(5-Amino-3-chlorophenyl)-4-methyl-1H-tetrazol-5(4H)-one 

Relevant articles and documents

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SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to pyrimidine compounds of formula (I), their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to process of preparation of these pyrimidine compounds, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders mediated by epidermal growth factor receptor (EGFR) family kinases.

Efficient and selective room-temperature gold-catalyzed reduction of nitro compounds with CO and H2O as the hydrogen source

[Chemical equation presented] Taking hydrogen from water: Gold catalysis enabled the selective reduction of nitro compounds under very mild conditions with a combination of H2O and CO as the reductant (see scheme). This environmentally friendly reaction proceeded in high yield and with high chemoselectivity in the presence of a wide range of functional groups