5344-83-2

Basic information

• Product Name: (2E)-2-(hydroxyimino)-1-(4-methoxyphenyl)propan-1-one
• CAS NO: 5344-83-2
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.1992
• Mol File: 5344-83-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 350.293°C at 760 mmHg
• Flash Point: 165.652°C
• Density: 1.143g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: (2E)-2-(hydroxyimino)-1-(4-methoxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-2-(hydroxyimino)-1-(4-methoxyphenyl)propan-1-one(5344-83-2)
• EPA Substance Registry System: (2E)-2-(hydroxyimino)-1-(4-methoxyphenyl)propan-1-one(5344-83-2)

Safety Data

• Hazardous Substances Data: 5344-83-2(Hazardous Substances Data)

Usage

Description

(2E)-2-(hydroxyimino)-1-(4-methoxyphenyl)propan-1-one, also known as methoxyphenyl-ketoxime, is an organic compound with the molecular formula C10H11NO3. It belongs to the ketoxime class and is commonly used in organic synthesis and pharmaceutical research. This chemical is known for its potential applications in the pharmaceutical industry, particularly in the development of new drugs and pharmaceutical intermediates. Its properties and structure make it a valuable compound for various research and industrial purposes. Additionally, it may have potential biological activities and pharmacological properties that warrant further investigation.

Uses

Used in Pharmaceutical Industry:
(2E)-2-(hydroxyimino)-1-(4-methoxyphenyl)propan-1-one is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure and properties make it a valuable compound in the synthesis of various pharmaceutical agents.
Used in Organic Synthesis:
(2E)-2-(hydroxyimino)-1-(4-methoxyphenyl)propan-1-one is used as a key component in organic synthesis, allowing for the creation of a wide range of chemical compounds for various applications.
Used in Research and Development:
(2E)-2-(hydroxyimino)-1-(4-methoxyphenyl)propan-1-one is used as a research compound to investigate its potential biological activities and pharmacological properties, contributing to the advancement of scientific knowledge in the field of chemistry and medicine.

Upstream product

• 65662-59-1 2-nitro-1-(4-methoxyphenyl)propanone 
• 121-97-1 4-Methoxypropiophenone 
• 100-66-3 methoxybenzene 
• 624-91-9 methyl nitrite 
• 110-46-3 isopentyl nitrite 
• 10557-27-4 1-(4-methoxy-phenyl)-propane-1,2-dione 
• 544-16-1 n-Butyl nitrite 

Downstream Products

• 132063-87-7 2-[3-Benzyl-5-(4-hydroxy-phenyl)-6-methyl-pyrazin-2-ylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 132063-77-5 2-[3-Benzyl-5-(4-hydroxy-phenyl)-6-methyl-pyrazin-2-ylamino]-3-(4-hydroxy-phenyl)-propionic acid 
• 123437-36-5 5-methylcoelenterazine 
• 132063-58-2 N-[3-Benzyl-5-(4-hydroxy-phenyl)-6-methyl-pyrazin-2-yl]-2-(4-hydroxy-phenyl)-acetamide 
• 123437-91-2 3-Benzyl-5-(4-methoxy-phenyl)-6-methyl-pyrazin-2-ylamine 
• 123437-58-1 4-(5-Amino-6-benzyl-3-methyl-pyrazin-2-yl)-phenol 
• 123437-81-0 3-Benzyl-5-(4-methoxy-phenyl)-6-methyl-1-oxy-pyrazin-2-ylamine 
• 4160-63-8 2-(4-methoxybenzoyl)thiophene 
• 701-53-1 p-methoxybenzoyl fluoride 

Relevant articles and documents

Visible-Light-Induced Transition-Metal-Free Nitrogen-Centered Radical Strategy for the Synthesis of 2-Acylated 9 H-Pyrrolo[1,2- a]indoles

A convenient and efficient visible-light-induced tandem acylation/cyclization of N-propargylindoles with aryl- or alkyl-substituted acyl oxime esters for the synthesis of 2-acyl-substituted 9H-pyrrolo[1,2-a]indoles under transition-metal-free conditions, which proceeds via nitrogen-centered radical-mediated cleavage of the C-C σ-bond in acyl oxime esters, is established. The aryl or alkyl acyl radicals, which come from acyl oxime esters, attack the C-C triple bonds in N-propargylindoles and then go through intramolecular cyclization/isomerization.

Photocatalytic C-C Bond Activation of Oxime Ester for Acyl Radical Generation and Application

A unified strategy to generate acyl radical from oxime ester via selective C-C bond activation is reported. Under visible-light irradiation, single-electron transfer from fac-Ir(ppy)3 to related oxime takes place followed by a fast β-fragment of C-C bond to yield aryl and aliphatic acyl radicals, subsequently captured by diverse Michael acceptors. More interestingly, the single-electron transfer enables coupling with energy transfer of the excited fac-Ir(ppy)3 via enone intermediate formed in situ for cyclobutane formation.

Functionalized α-oximinoketones as building blocks for the construction of imidazoline-based potential chiral auxiliaries

Functionalized α-oximinoketones with β-alkoxy, β-alkyl, and β-sulfenyl groups were used as efficient synthons for the preparation of chiral 1-acyl-4-imidazolin-2-ones and 1-acylimidazolidin-2-ones. For the preparation of the former heterocycles, α-oximinoketones were transformed into their respective imidazole N-oxides by neutral treatment with a chiral triazine, followed by reaction with acetic or propionic anhydrides to furnish the desired chiral 1-acetyl- or 1-propionyl-4-imidazolin-2-ones in moderate overall yields. Upon palladium hydroxide-catalyzed hydrogenation, these series were converted into their corresponding 1-acylimidazolidin-2-ones in high diastereoisomeric ratios. Thus, these novel chiral 1-acetyl- and 1-propionyl-imidazolidin-2-ones were obtained with a variety of alkyl groups at the C-4 and C-5 positions of the heterocycle, through a three-step methodology, and can be applied as new potential chiral auxiliaries.