5344-89-8Relevant articles and documents
Metal-free conversion of methane and cycloalkanes to amines and amides by employing a borylnitrene
Bettinger, Holger F.,Filthaus, Matthias,Bornemann, Holger,Oppel, Iris M.
supporting information; body text, p. 4744 - 4747 (2009/02/06)
(Chemical Equation Presented) C-H insertion: Borylnitrenes, which are generated in situ by photoylsis of azides, convert unactivated alkanes by intermolecular C-H insertion into aminoboranes (see scheme), which in turn can be reacted further to give amines or amides. The boryl group serves two purposes: it converts the nitrene into a highly reactive BN vinylidene analogue, and it is easily cleaved from the product.
Synthesis of 2H- and 3H-labelled iptakalim hydrochloride
Zhang, Cheng,Yang, Rifang,Chen, Lanfu,Zhong, Bohua,Yun, Liuhong,Wang, Hai
, p. 583 - 590 (2007/10/03)
Iptakalim hydrochloride (N-(1-methylethyl)-1,1,2-trimethyl-propylamine hydrochloride) is a promising antihypertensive drug discovered and developed by Beijing Institute of Pharmacology and Toxicology. Deuterium- and tritium-labelled compounds were designed and synthesized for pharmacokinetic and pharmacological mechanism studies. A derivatization method has been employed in the synthesis procedure. Copyright