53459-50-0

Basic information

• Product Name: NH₂-Gly-Phe-OBn
• Synonyms: NH₂-Gly-Phe-OBn
• CAS NO: 53459-50-0
• Molecular Weight: 312.368
• Mol File: 53459-50-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: NH₂-Gly-Phe-OBn(CAS DataBase Reference)
• NIST Chemistry Reference: NH₂-Gly-Phe-OBn(53459-50-0)
• EPA Substance Registry System: NH₂-Gly-Phe-OBn(53459-50-0)

Safety Data

• Hazardous Substances Data: 53459-50-0(Hazardous Substances Data)

Upstream product

• 5519-03-9 2-(2-tert-butoxycarbonylamino-acetylamino)-3-phenyl-propionic acid benzyl ester 
• 962-39-0 L-Phenylalanine benzyl ester 

Downstream Products

• 189580-68-5 (S)-2-(2-{(S)-3-(1H-Indol-3-yl)-2-[(pyridine-2-carbonyl)-amino]-propionylamino}-acetylamino)-3-phenyl-propionic acid benzyl ester 

Relevant articles and documents

Peptide-Catalyzed Highly Asymmetric Cross-Aldol Reaction of Aldehydes to Biomimetically Synthesize 1,4-Dicarbonyls

β-Turn tetrapeptides were demonstrated to catalyze asymmetric aldol reaction of α-branched aldehydes and α-carbonyl aldehydes, i.e. glyoxylates and α-ketoaldehydes, to biomimetically synthesize acyclic all-carbon quaternary center-bearing 1,4-dicarbonyls in high yield and excellent enantioselectivity under mild conditions. The spatially restricted environment of the tetrapeptide warrants high enantioselectivity and yield with broad substrates. Using this protocol, (R)-pantolactone, the key intermediate of vitamin B5, was readily accessed in a practical, efficient, and environmentally benign process from inexpensive starting materials.

Electrochemical removal of the picolinoyl group under mild acidic conditions, application to the protection of amines in peptide synthesis

The picolinoyl group can be used as a convenient protective group for amines in peptide chemistry. Deprotection is performed by electrochemical reduction under mild acidic conditions.