534595-53-4

Basic information

• Product Name: N-isopropylpiperidin-4-amine
• Synonyms: N-isopropylpiperidin-4-amine;4-Isopropylpiperidin-4-aMine;4-Isopropylaminopiperidine;N-(1-Methylethyl)-4-isopropylaMinopiperidine;N-(1-Methylethyl)-4-piperidinaMine;4-PiperidinaMine, N-(1-Methylethyl)-
• CAS NO: 534595-53-4
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24192
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 534595-53-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 194℃
• Flash Point: 68℃
• Appearance: /
• Density: 0.89
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.40±0.20(Predicted)
• CAS DataBase Reference: N-isopropylpiperidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-isopropylpiperidin-4-amine(534595-53-4)
• EPA Substance Registry System: N-isopropylpiperidin-4-amine(534595-53-4)

Safety Data

• Hazardous Substances Data: 534595-53-4(Hazardous Substances Data)

Usage

Description

N-isopropylpiperidin-4-amine is an organic compound with the molecular formula C10H22N2. It is a derivative of piperidine, featuring an isopropyl group attached to the nitrogen atom. N-isopropylpiperidin-4-amine is known for its potential applications in the pharmaceutical industry due to its unique structural properties and interactions with biological targets.

Uses

Used in Pharmaceutical Industry:
N-isopropylpiperidin-4-amine is used as an intermediate in the synthesis of 6-substituted benzoxazines. These benzoxazines serve as 5-HT5A antagonists, which are crucial for the treatment of various mental disorders. By modulating the serotonin 5-HT5A receptors, these antagonists can help alleviate symptoms associated with mental health conditions.
Used in Preparation of Antagonists:
N-isopropylpiperidin-4-amine is utilized as a key component in the preparation of 6-substituted benzoxazines that act as 5-HT5A antagonists. These antagonists are specifically designed to target and block the serotonin 5-HT5A receptors, playing a significant role in the treatment of mental disorders. N-isopropylpiperidin-4-amine's structural characteristics enable it to form stable and effective antagonists, making it a valuable asset in the development of novel therapeutic agents for mental health.

Upstream product

• 132442-32-1 1-benzyl-4-(1-methylethylamino)piperidine 

Downstream Products

• 871828-51-2 4-isopropylamino-piperidine-1-carbothioic acid amide 

Relevant articles and documents

Process for preparing substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds

Processes and intermediates for preparing substituted 4-amino-1-(pyridylmethyl)-piperidine and related compounds in high yield and high purity are described. The substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds prepared by the describ