53464-60-1

Basic information

• Product Name: L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, 5-methyl ester
• CAS NO: 53464-60-1
• Molecular Formula: C20H21N7O6
• Molecular Weight: 455.43
• Mol File: 53464-60-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, 5-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, 5-methyl ester(53464-60-1)
• EPA Substance Registry System: L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, 5-methyl ester(53464-60-1)

Safety Data

• Hazardous Substances Data: 53464-60-1(Hazardous Substances Data)

Upstream product

• 1499-55-4 L-glutamic acid 5-methyl ester 
• 197151-79-4 pteroyl azide 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 59-30-3 folic acid 
• 197151-68-1 pteroyl hydrazide 
• 197151-80-7 N¹⁰-nitrosopteroyl azide 
• 223378-69-6 pyrofolic acid 
• 223378-68-5 N¹⁰-(trifluoroacetyl)pyrofolic acid 

Downstream Products

• 197151-85-2 N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-aminoethyl)-L-glutamine 

Relevant articles and documents

Novel compositions magnetic particles covered with gem-bisphosphonate derivatives

The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: [in-line-formulae]X-L-CH(PO3H2)2 ??(I)[/in-line-formulae]in which: L represents an organic group connecting the X group to the gem-bisphosphonate group —CH(PO3H2)2;X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).

Efficient syntheses of pyrofolic acid and pteroyl azide, reagents for the production of carboxyl-differentiated derivatives of folic acid

Reaction of folic acid (1) with excess trifluoroacetic anhydride provides access to both the previously unknown N10-(trifluoroacetyl)pyrrofolic acid (8) and pyrofolic acid (9). Reaction of either of these materials with hydrazine selectively affords pteroyl hydrazide (13), which may be oxidized to pteroyl azide (27) on a large scale (62% overall from I without the need for chromatography). Treatment of 27 with differentially protected glutamates provides a convenient and high-yielding synthesis of differentially protected, optically pure folates.