53474-08-1

Basic information

• Product Name: 3-bromo-4,5-dimethoxyphenylamine
• Synonyms: 3-bromo-4,5-dimethoxyphenylamine
• CAS NO: 53474-08-1
• Molecular Weight: 232.077
• Mol File: 53474-08-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-bromo-4,5-dimethoxyphenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-4,5-dimethoxyphenylamine(53474-08-1)
• EPA Substance Registry System: 3-bromo-4,5-dimethoxyphenylamine(53474-08-1)

Safety Data

• Hazardous Substances Data: 53474-08-1(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 6948-30-7 5-bromoveratralaldehyde 
• 781654-31-7 3-bromo-4,5-dimethoxybenzonitrile 
• 52805-45-5 5-bromo-4-hydroxy-3-methoxybenzonitrile 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 6324-52-3 3-bromo-4-hydroxy-5-methoxybenzoic acid 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 35488-15-4 2-methoxy-4-nitro-6-bromophenol 
• 712294-58-1 3-bromo-4,5-dimethoxybenzamide 
• 7461-55-4 3-bromo-5-nitrocatechol dimethyl ether 

Relevant articles and documents

3-bromo-5-amino-catechol dimethyl ether synthesis method

The invention relates to a 3-bromo-5-amino-catechol dimethyl ether synthesis method, which comprises the following three steps: S1, brominating by using 2-methoxy-4-nitrophenol as a starting raw material to obtain 2-methoxy-4-nitro-6-bromophenol; S2, carr

Biphenyl derivatives incorporating urea unit as novel VEGFR-2 inhibitors: Design, synthesis and biological evaluation

A series of novel biphenyl urea derivates were synthesized and investigated for their potential to inhibit vascular endothelial growth factor receptor-2 (VEGFR-2). In particular, A7, B3 and B4 displayed significant enzymatic inhibitory activities, with IC50 values of 4.06, 4.55 and 5.26 nM. Compound A7 exhibited potent antiproliferative activity on several cell lines. SAR study suggested that the introduction of methyl at ortho-position of the biphenyl urea and tertiary amine moiety could improve VEGFR-2 inhibitory activity and antitumor effects. Molecular docking indicated that the urea moiety formed four hydrogen bonds with DFG residue. These biphenyl ureas could serve as promising lead compounds for further optimization.