53497-48-6

Basic information

• Product Name: 1H-Indole-2-thiol, 1-methyl-
• Synonyms: 1H-Indole-2-thiol, 1-methyl-
• CAS NO: 53497-48-6
• Molecular Formula: C9H9NS
• Molecular Weight: 163.24
• Mol File: 53497-48-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole-2-thiol, 1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-thiol, 1-methyl-(53497-48-6)
• EPA Substance Registry System: 1H-Indole-2-thiol, 1-methyl-(53497-48-6)

Safety Data

• Hazardous Substances Data: 53497-48-6(Hazardous Substances Data)

Upstream product

• 13637-38-2 1-methyl-2-indolinethione 

Relevant articles and documents

Carboxylic acid amide enols: Keto-enol/enolate interconversion of N-methylindoline-2-one and its 2-thione and 2-selone analogs in aqueous solution

Carbon-acid ionization constants, Q(a)(K) (concentration quotiem at ionic strength = 0.10 M), were determined by spectrophotometric titration in aqueous solution for N- methylindoline-2-one, pQ(a)(K) = 15.70, N-methylindoline-2-thione, pQ(a)(K) = 8.93, and N-methylindoline-2-selone, pQ(a)(K) = 7.25. Rate profiles were also constructed for the thione and selone. These were interpreted, with support from the form of acid-base catalysis as well as solvent and substrate isotope effects, as representing keto - enol/enolate ion interconversion. That led to the enol acidity constant pQ(a)(E) = 4.05 and the keto-enol equilibrium constant pK(E) = 4.88 for the thione and estimates of the limits on these quantities, pQ(a)(E) 4, for the selone.