5351-90-6Relevant articles and documents
THIOSEMICARBAZONES INHIBITORS OF LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE AND USES THEREOF
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Page/Page column 15, (2015/11/17)
Lysophosphatidic acid acyltransferase-beta (LPAAT-β) catalyzes the production of phosphatidic acid (PA) from lysophosphatidic acid (LPA). The lipid cofactor PA contributes to the activation of c-Raf, BRAF, mTOR and PKC-ζ. LPAAT-β expression is a prognostic factor in gynecologic malignancies and is being investigated as a therapeutic target in a variety of tumor types. A class of thiosemicarbazones was identified as inhibitors of LPAAT-β from a screen of a library of small molecules. A focused library of thiosemicarbazones derivatives was prepared and led to the development of compounds which potently inhibit LPAAT-β and inhibit the growth of MiaPaCa2 human pancreatic cancer cells.
Synthesis, characterization, and structure of some silicon containing diorganotin(IV) complexes of salicylaldehyde thiosemicarbazones
Wang, Qibao,Ding, Ruifang,Wen, Xinmin,Yin, Fujun
, p. 895 - 903 (2013/08/23)
Four diorganotin(IV) complexes, bis[(trimethylsilyl)methyl]tin salicylaldehyde thiosemicarbazonate monohydrate(1), bis[(trimethylsilyl)methyl] tin 3-methoxysalicylaldehyde thiosemicarbazonate (2), bis[(trimethylsilyl) methyl]tin 5-tert-butyl-3-methylsalicylaldehyde thiosemicarbazonate (3), and bis[(trimethylsilyl)methyl]tin 2-oxylnaphthaldehyde thiosemicarbazonate (4) have been synthesized by reactions of (Me3SiCH2) 2SnCl2 with the corresponding semicarbazone. The four complexes were characterized by IR and NMR spectroscopy and elemental analyses. The X-ray studies of compounds 1 and 4 showed that the thiosemicarbazone ligands act as tridentate ligands chelating to the central tin atoms, and thus the tin atoms were five coordinated in trigonal bipyramidal geometry for both compounds. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
Spectroscopic, thermal and electrochemical studies on some nickel(II) thiosemicarbazone complexes
El-Shazly,Al-Hazmi,Ghazy,El-Shahawi,El-Asmy
, p. 243 - 252 (2007/10/03)
Several complexes of thiosemicarbazone derivatives with Ni(II) have been prepared. Structural investigation of the ligands and their complexes has been made based on elemental analysis, magnetic moment, spectral (UV-Vis, i.r., 1H NMR, ms), and