53526-25-3

Basic information

• Product Name: 6-Methoxy-2-heptanonaphthone
• Synonyms: 6-METHOXY-2-HEPTANONAPHTHONE;1-(6-METHOXY-2-NAPHTHALENYL)-1-HEPTANONE;6-METHOXY-1-NAPHTHALENYL-1-HEPTANONE;1-(6-METHOXY-2-NAPHTHALENYL)-HEPANONE;6-METHOXY-2-HEPTANONAPHTHONE, 99+%;1-(6-Methoxy-naphthalen-2-yl)-heptan-1-one
• CAS NO: 53526-25-3
• Molecular Formula: C₁₈H₂₂O₂
• Molecular Weight: 270.37
• Mol File: 53526-25-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 68-69 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 408.93 °C at 760 mmHg
• Flash Point: 172.176 °C
• Appearance: /
• Density: 1.033 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Methoxy-2-heptanonaphthone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxy-2-heptanonaphthone(53526-25-3)
• EPA Substance Registry System: 6-Methoxy-2-heptanonaphthone(53526-25-3)

Safety Data

• Hazardous Substances Data: 53526-25-3(Hazardous Substances Data)

Usage

General Description

6-Methoxy-2-heptanonaphthone is a chemical compound also known as 2-Heptanone, 6-methoxy-naphthalen-2-ylketone. It is a ketone with a molecular formula of C14H16O2, and a molecular weight of 216.28 g/mol. 6-Methoxy-2-heptanonaphthone is commonly used in the manufacturing of perfumes and fragrances, as well as in the production of flavors and fragrances for the food industry. Its structure includes a naphthalene ring with a methoxy group (CH3O) at the 6-position and a ketone group (C=O) at the 2-position. This chemical is known to have a strong, sweet, and floral odor, making it a valuable ingredient in the fragrance industry. Additionally, it possesses potential biological activities, and research is ongoing to explore its various applications and properties.

InChI:InChI=1/C18H22O2/c1-3-4-5-6-7-18(19)16-9-8-15-13-17(20-2)11-10-14(15)12-16/h8-13H,3-7H2,1-2H3

Upstream product

• 3453-33-6 6-methoxynaphthalene-2-carbaldehyde 
• 3761-92-0 n-hexylmagnesium bromide 
• 481631-56-5 1-(6-methoxy-2-naphthyl)heptan-1-ol 
• 21369-64-2 n-hexyllithium 
• 158689-13-5 7-methoxy-1-naphthyl phenyl ketone 
• 5672-94-6 1-acetyl-2-methoxynaphthalene 
• 93-04-9 2-Methoxynaphthalene 
• 2528-61-2 Heptanoic acid chloride 

Downstream Products

• 481631-57-6 2-(6-methoxy-[2]naphthyl)-3-pentyl-indole 
• 481631-58-7 1-benzyl-2-(6-methoxynaphthalen-2-yl)-3-pentyl-1H-indole 
• 17493-88-8 6-Hydroxy-2-heptyl-naphthalin 
• 53526-26-4 1-(6-hydroxy-[2]naphthyl)-heptan-1-one 

Relevant articles and documents

PROCESSES AND COMPOUNDS FOR THE PREPARATION OF SUBSTITUTED NAPHTHYLINDOLE DERIVATIVES

The present invention provides processes for the preparation of substituted naphthyl indole derivatives of formula (I) that can be used as inhibitors of plasminogen activator inhibitor-1 (PAI-I) . In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyl tetrazole with a substituted naphthol.

Acylation of 2-Methoxynaphthalene with Acyl Clorides in the Presence of a Catalytic Amount of Lewis Acids

The regiochemistry of the reaction of 2-methoxynaphthalene 1 with benzoyl chloride 2a using a catalytic amount of Lewis acid is strongly influenced by the identity of the acid catalyst employed as well as by the reaction temperature.By using InCl3, FeCl3, SnCl4 or ZnCl2 and heating at 160 deg C, 2-benzoyl-6-methoxynaphthalene 4a is selectively produced along with 1-benzoyl-7-methoxynaphthalene 5a, while in the case of AlCl3, SbCl5 or TiCl4, 1-benzoyl-2-methoxynaphthalene 3a is the major product. 2-Acyl-6-methoxynaphthalenes 4b-e can be selectively obtained using InCl3 and the corresponding acyl chlorides 2b-e in place of 2a.In the presence of a stoichiometric amount of InCl3, the reaction of 1 with 2a also gives 4a as the predominant product along with 5a even at 50 deg C.This reaction appears to involve isomerisation of 3a to 4a and 5a.