53527-18-7

Basic information

• Product Name: Acetamide, 2-chloro-N-(3,4-dihydroxyphenyl)- (9CI)
• Synonyms: Acetamide, 2-chloro-N-(3,4-dihydroxyphenyl)- (9CI)
• CAS NO: 53527-18-7
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.60702
• Product Categories: ALCOHOL
• Mol File: 53527-18-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetamide, 2-chloro-N-(3,4-dihydroxyphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-chloro-N-(3,4-dihydroxyphenyl)- (9CI)(53527-18-7)
• EPA Substance Registry System: Acetamide, 2-chloro-N-(3,4-dihydroxyphenyl)- (9CI)(53527-18-7)

Safety Data

• Hazardous Substances Data: 53527-18-7(Hazardous Substances Data)

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Relevant articles and documents

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF

Catechol-based inhibitors of ERCC1-XPF endonuclease activity were identified from a high-throughput screen. Exploration of the structure-activity relationships within this series yielded compound 13, which displayed an ERCC1-XPF IC50 of 0.6 μM, high selectivity against FEN-1 and DNase I and activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays in A375 melanoma cells. Screening of fragments as potential alternatives to the catechol group revealed that 3-hydroxypyridones are able to inhibit ERCC1-XPF with high ligand efficiency, and elaboration of the hit gave compounds 36 and 37 which showed promising ERCC1-XPF IC50 values of 10 μM.