53544-45-9Relevant articles and documents
A Radical-Polar Crossover Annulation to Access Terpenoid Motifs
Thomas, William P.,Schatz, Devon J.,George, David T.,Pronin, Sergey V.
supporting information, p. 12246 - 12250 (2019/08/27)
A new catalytic radical-polar crossover annulation between two unsaturated carbonyl compounds is described. The annulation proceeds under exceptionally mild conditions and provides direct and expedient access to complex terpenoid motifs. Application of this chemistry allows for synthesis of forskolin, a densely functionalized terpenoid, in 14 steps from commercially available material.
Pd(II)-catalyzed intramolecular amidoarylation of alkenes with molecular oxygen as sole oxidant
Yip, Kai-Tai,Yang, Dan
supporting information; experimental part, p. 2134 - 2137 (2011/06/19)
Stereoselective palladium-catalyzed synthesis of structurally versatile indoline derivatives, using molecular oxygen as the sole oxidant, is described. New C-N and C-C bonds form across an alkene in an intramolecular manner. The C-N bond-forming step proceeds via a syn-amidopalladation pathway. The moderate kinetic isotope effects (intramolecular KIE = 3.56) suggest that electrophilic aromatic substitution occurs in the arylation step.
Intermolecular photoreaction of benzenecarbothioamide with γ, δ-unsaturated ketones: Application to synthesis of cycloalkane [c]-fused pyridines
Oda, Kazuaki,Haneda, Michiko,Nishizon, Naozumi,Machida, Minoru
, p. 563 - 566 (2007/10/03)
Irradiation of benzenecarbothioamide with (2-methylene-cycloalkyl)acetaldehyde in benzene gives cycloalkane [c]-fused pyridines in moderate yields.
