53557-70-3

Basic information

• Product Name: Ethanimidic acid, 2-cyano-, methyl ester, monohydrochloride
• Synonyms: .2-cyano-acetimidic acid methyl ester, hydrochloride;.(2-cyano-1-methoxy-ethylidene)ammonium chloride;.methyl cyanoacetimidate hydrochloride;.2-Cyan-acetimidsaeure-methylester, Hydrochlorid;.Cyanacetamidsaeure-methylester-hydrochlorid;methyl Cyanoacetimidate Hydrochloride
• CAS NO: 53557-70-3
• Molecular Formula: C4H6N2O.ClH
• Molecular Weight: 134.56400
• Mol File: 53557-70-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanimidic acid, 2-cyano-, methyl ester, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanimidic acid, 2-cyano-, methyl ester, monohydrochloride(53557-70-3)
• EPA Substance Registry System: Ethanimidic acid, 2-cyano-, methyl ester, monohydrochloride(53557-70-3)

Safety Data

• Hazardous Substances Data: 53557-70-3(Hazardous Substances Data)

Upstream product

• 109-77-3 malononitrile 
• 67-56-1 methanol 

Downstream Products

• 1418199-92-4 ((S)-6-benzenesulfonyl-1-tetrahydro-pyran-3-yl-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-acetonitrile 
• 917486-82-9 2-cyanomethyl-5-(tert-butyldiphenylsilyloxymethyl)benzimidazole 
• 3289-66-5 2-chloro-4-amino-6-methoxypyrimidine 
• 70138-31-7 2-cyano-1,1,1-trimethoxyethane 
• 136773-45-0 2-Amino-2-benzoylhydrazinoethene-1-carbonitrile 

Relevant articles and documents

PYRAZOLYL-AMINO-SUBSTITUTED PYRAZINES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These novel compounds provide a treatment for myeloproliferative disorders and cancer.

Activated propenes as color couplers method for the production thereof

The invention provides novel photographic compositions comprising a propene isomer of the formula wherein A B or E, each individually represent hydrogen, or an electron withdrawing group, selected for example from —CN, —NO2, —SO2R, —SO2NH—, —CO2R, —COR, —CONHR, —CONHAr, —CF3halogen, amino, aryl, aralkyl, alkyl, cycloalkyl, alkyl (carbonyl)oxy, aryl (carbonyl)oxy, carboxy, alkoxycarbonyl, aryloxycarbonyl, carbamomyl, acyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonylamino, acylamino, ureido, alkylsulphonylamino, arylsulphonylamino, sulphamoylamino, alkylsulphonyl, arylsulphonyl, sulphamoyl, imido, alkylthio, arylthio and heterocycles; the invention also provides a propene isomer of the formula I wherein D represents a group of the formula Ar—L— wherein Ar is a phenyl group optionally substituted with one or more substituents, and —L— is a linking group incorporating a lone pair of electrons; and A, B, E and X are defined as R is above defined. The activated propenes of the above formulae are novel colour couplers which react with oxidised developer under alkaline conditions to give magenta dyes.

Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17α-esters containing a functional group

A series of 21-desoxy-21-chlorocorticosteroids that contain a functionalized ester group at 17α has been prepared and examined to separate their systemic activity from topical antiinflammatory activity. Introduction of the functionalized ester group at 17α was carried out by an acid-catalyzed formation of cyclic ortho esters with 17α,21-hydroxyl groups of corticosteroids and subsequent acid-catalyzed hydrolysis. As for the functional group, chloro, methoxy, acetoxy, cyano, cyclopropyl, or alkoxycarbonyl group was introduced at the terminal carbon atom of the 17α-alkanoate group. The topical antiinflammatory activity and systemic activity of these compounds were examined and found to be signficantly dependent on the functionalities in the 17α-esters. Among these derivatives, a series of 17α-(alkoxycarbonyl)alkanoates (17α-OCO(CH2)(n)COOR) showed an excellent separation of the systemic activity from topical activity. The effects of the number of methylene groups (n) and of the alkyl groups of the ester (R) on either topical or systemic activity of the corticosteroid derivatives were also investigated.