5365-23-1Relevant articles and documents
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Khusid,A.Kh. et al.
, p. 428 - 430 (1977)
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ARYL, HETEROARY, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS
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Page/Page column 48, (2018/09/21)
Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
Reduction of Cyclopropanecarboxylic Acids by Borane, a Chemoselective Reaction Sensitive to Steric Interactions and Reaction Conditions
Sydnes, Leiv K.,Pereira, Paula F. F.,Sandberg, Marcel,Oevreboe, Hans H.
, p. 464 - 474 (2007/10/03)
A number of cyclopropanecarboxylic acids have been reduced by borane in tetrahydrofuran to the corresponding cyclopropyl alcohols. The yield was sensitive to the steric influence of the substituents attached to the ring, the reaction temperature, and the