536975-50-5 Usage
Description
[Difluoro(phenylsulfonyl)methyl]trimethylsilane, with the molecular formula C11H15F2OSi, is a silane compound utilized as a reagent in organic synthesis. It is characterized by its unique structure and properties, making it a valuable component in the production of pharmaceuticals, agrochemicals, and specialty chemicals. [difluoro(phenylsulfonyl)Methyl]triMethyl-Silane holds potential in the field of medicinal chemistry, particularly in the development of new drugs, and serves as a trimethylsilylating reagent for the protection and functionalization of various functional groups in organic molecules. It also acts as a versatile building block for the synthesis of complex organic compounds.
Uses
Used in Pharmaceutical Industry:
[Difluoro(phenylsulfonyl)methyl]trimethylsilane is used as a reagent for the synthesis of various pharmaceuticals due to its ability to protect and functionalize different functional groups in organic molecules. Its unique structure and properties contribute to the development of new drugs with enhanced efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical industry, [difluoro(phenylsulfonyl)methyl]trimethylsilane is used as a reagent for the production of agrochemicals. Its role in protecting and functionalizing functional groups in organic molecules aids in the development of more effective and targeted agrochemical products.
Used in Specialty Chemicals Industry:
[Difluoro(phenylsulfonyl)methyl]trimethylsilane is also used as a reagent in the synthesis of specialty chemicals. Its versatility as a trimethylsilylating agent and a building block for complex organic compounds makes it a valuable asset in this industry, enabling the creation of innovative and high-performance specialty chemicals.
Used in Medicinal Chemistry Research:
[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane is used as a research tool in medicinal chemistry for the development of new drugs. Its ability to protect and functionalize various functional groups in organic molecules makes it a valuable asset in the design and synthesis of novel drug candidates with improved pharmacological properties.
Overall, [difluoro(phenylsulfonyl)methyl]trimethylsilane is a valuable and versatile chemical reagent with significant synthetic and medicinal applications across various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 536975-50-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,3,6,9,7 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 536975-50:
(8*5)+(7*3)+(6*6)+(5*9)+(4*7)+(3*5)+(2*5)+(1*0)=195
195 % 10 = 5
So 536975-50-5 is a valid CAS Registry Number.
536975-50-5Relevant articles and documents
Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent
Ismalaj, Ermal,Le Bars, Didier,Billard, Thierry
, p. 4790 - 4793 (2016)
The (benzenesulfonyl)difluoromethylsulfanyl (PhSO2CF2S) group is a valuable substituent with specific properties which can provide access to new applications of fluoroalkylthiolated compounds. Direct introduction of this moiety can be performed by in an electrophilic manner by using a new shelf-stable reagent, namely a (benzenesulfonyl)difluoromethanesulfenamide. Furthermore, mild magnesium-mediated reduction of the PhSO2CF2S group leads to a facile synthesis of difluoromethylthiolated molecules and their deuterated analogs. Chameleon-like reactivity: (Benzenesulfonyl)difluoromethanesulfenamide was developed as a new, shelf-stable reagent for the introduction of the PhSO2CF2S group into organic molecules (see scheme). The versatility of the PhSO2 moiety also provides an entry into reductive deuterations.
An easier and quicker access to (benzenesulfonyl)difluoromethanesulfenamide reagent
Ismalaj, Ermal,Billard, Thierry
, p. 215 - 217 (2017/10/05)
(Benzenesulfonyl)difluoromethanesulfenamide (PhSO2-BB12H) is an interesting reagent to lead to various fluoroalkylselenotated molecules. This compound is obtained from [(benzenesulfonyl)difluoromethyl]trimethylsilane. Herein, a new process in two steps, w
Copper-mediated fluoroalkylation reactions with [(phenylsulfonyl)- difluoromethyl]trimethylsilane: Synthesis of PhSO2CF 2-containing allenes and alkynes
Zhu, Jieming,Wang, Fei,Huang, Weizhou,Zhao, Yanchuan,Ye, Wenchao,Hu, Jinbo
supporting information; experimental part, p. 899 - 902 (2011/06/19)
Copper-mediated (phenylsulfonyl)difluoromethylation of propargyl chlorides and alkynyl halides with PhSO2CF2TMS reagent was successfully achieved to give PhSO2CF2-containing allenes and alkynes, respectively. It is believed that the in situ formed PhSO 2CF2Cu species is involved in the present (phenylsulfonyl)difluoromethylation reactions. Georg Thieme Verlag Stuttgart · New York.
