5372-78-1

Basic information

• Product Name: 4-chloro-N-cyanobenzamide
• CAS NO: 5372-78-1
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.5911
• Mol File: 5372-78-1.mol
• Article Data: 5

Chemical Properties

• Density: 1.336g/cm³
• Refractive Index: 1.575
• CAS DataBase Reference: 4-chloro-N-cyanobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-cyanobenzamide(5372-78-1)
• EPA Substance Registry System: 4-chloro-N-cyanobenzamide(5372-78-1)

Safety Data

• Hazardous Substances Data: 5372-78-1(Hazardous Substances Data)

Upstream product

• 19981-17-0 sodium cyanamide 
• 74-11-3 para-chlorobenzoic acid 
• 106-39-8 bromochlorobenzene 
• 420-04-2 CYANAMID 
• 201230-82-2 carbon monoxide 
• 122-01-0 4-chloro-benzoyl chloride 
• 3911-57-7 (4-chloro-benzoyl)-carbonimidic acid dichloride 

Downstream Products

• 376372-56-4 4-chloro-N-(4-oxo-4H-1,3-benzothiazin-2-yl)benzamide 
• 700855-89-6 2-(4-chlorophenylcarboxamido)-4-phenylquinazoline 
• 140617-00-1 2-(4-chlorophenylcarboxamido)-3,4-dihydroquinazolin-4-one 
• 810637-91-3 6-(4-chlorophenylcarboxamido)-8-methyl[1,3]dioxolo[4,5-g]quinazoline 
• 478489-90-6 4-chloro-N-(N-hydroxy-amidine)benzamide 
• 6940-51-8 N-carbamoyl-4-chlorobenzamide 
• 23275-53-8 5-(4-chlorophenyl)-1,2,4-oxadiazol-3-amine 
• 36055-54-6 C₈H₄Cl₅N₂OP 

Relevant articles and documents

Ultrasound-Assisted Synthesis of N -Acylcyanamides and N -Acyl-Substituted Imidazolones from Carboxylic Acids by Using Trichloroisocyanuric Acid/Triphenylphosphine

A convenient ultrasound-assisted one-pot synthesis of N -acylcyanamides starting from readily available carboxylic acids and sodium cyanamide has been developed. Upon activation in the presence of trichloroisocyanuric acid (TCCA) and triphenylphosphine, a range of carboxylic acids was converted into N -acylcyanamides in good to excellent yields within 10 minutes at room temperature without base. Remarkably, N -acyl-substituted imidazolones were readily accessible through guanylation-cyclization of the in situ generated N -acylcyanamides.

Palladium-catalyzed carbonylative synthesis of N-cyanobenzamides from aryl iodides/bromides and cyanamide

A novel and convenient protocol for the synthesis of N-cyanobenzamides starting from readily available aryl halides and cyanamide via palladium-catalyzed aminocarbonylation has been developed. The protocol utilizes Mo(CO)6 as the CO source or CO(gas) and affords the desired N-cyanobenzamides in moderate to good yields.

Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.