53750-68-8Relevant articles and documents
Enantioselective synthesis of (1R,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-exo-carboxylic acid
Wirz, Beat,Spurr, Paul,Pfleger, Christophe
, p. 159 - 161 (2010)
A scalable enantioselective access to (1R,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-exo-carboxylic acid 7, a key precursor in the synthesis of A2a receptor antagonist 1 by means of an enzymatic resolution of the respective butyl ester with lipase A from Candida antarctica, is described.
N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities
-
Paragraph 0249, (2014/09/29)
Described are compounds of Formula 1 which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
Niobium(V) chloride as catalyst in diels-alder reaction of furan ring
Santos, Deborah A. Dos,Rodrigues, Ludmila R.,Arpini, Bruno H.,Lacerda Jr., Valdemar,Greco, Sandro J.,Santos, Reginaldo B. Dos,Neto, A?lvaro C.,Roma?oa, Wanderson,De Castro, Eustaquio V.R.
, p. 882 - 886 (2014/06/24)
According to the relevant literature, the Diels-Alder reaction of furan without a catalyst can last several weeks and shows a low yield due to the diene's low reactivity. The use of Lewis acid catalysts or high pressures is described as an effective method for improving the reaction yields. This paper describes our recent study on the use of niobium pentachloride as the catalyst in Diels-Alder reactions between furan and several reactive dienophiles, among which methyl acrylate showed good yields, especially at lower temperatures. Other dienophiles have shown lower yields because of problems such as byproduct formation and the high reversibility of the reaction.
