53760-19-3 Usage
Description
Cytochalasin H is a potent mycotoxin derived from a range of fungi. It significantly impacts cytoskeletal proteins, leading to notable morphogenic changes in both animals and plants. Cytochalasin H has demonstrated various biological activities, including antibacterial, antifungal, nematocidal, and antitumor properties.
Uses
Used in Pharmaceutical Industry:
Cytochalasin H is used as a research tool for studying the cytoskeleton and its role in cellular processes due to its ability to bind and disrupt actin filaments. This helps researchers understand the mechanisms behind cell movement, division, and shape.
Used in Antimicrobial Applications:
Cytochalasin H is used as an antimicrobial agent for its antibacterial and antifungal properties, making it a potential candidate for developing new treatments against resistant strains of bacteria and fungi.
Used in Pest Control:
Due to its nematocidal activity, Cytochalasin H can be used as a biopesticide to control nematode populations, which are harmful to crops and can cause significant agricultural losses.
Used in Anticancer Applications:
Cytochalasin H is used as an antitumor agent, exhibiting potential in the development of novel cancer therapies. Its ability to disrupt the cytoskeleton may lead to the inhibition of tumor growth and the prevention of metastasis in various types of cancer.
Used in Drug Delivery Systems:
Cytochalasin H can be incorporated into drug delivery systems to enhance its bioavailability and targeting capabilities. This may involve the use of nanoparticles or other carriers to improve the compound's delivery to specific cells or tissues, increasing its therapeutic effectiveness.
Safety Profile
Poison by intravenous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 53760-19-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,7,6 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 53760-19:
(7*5)+(6*3)+(5*7)+(4*6)+(3*0)+(2*1)+(1*9)=123
123 % 10 = 3
So 53760-19-3 is a valid CAS Registry Number.
InChI:InChI=1/C30H39NO5/c1-18-10-9-13-23-27(33)20(3)19(2)26-24(16-22-11-7-6-8-12-22)31-28(34)30(23,26)25(36-21(4)32)14-15-29(5,35)17-18/h6-9,11-15,18-19,23-27,33,35H,3,10,16-17H2,1-2,4-5H3,(H,31,34)/b13-9+,15-14+/t18-,19+,23-,24-,25+,26-,27+,29+,30?/m0/s1
53760-19-3Relevant articles and documents
Cytochalasan synthesis: Total synthesis of cytochalasin H
Thomas, Eric J.,Whitehead, John W. F.
, p. 507 - 518 (2007/10/02)
Cytochalasin H (2) has been synthesized using an intramolecular Diels-Alder reaction to form the [11]cytochalasan skeleton. This was highly stereoselective and gave adduct (49) with the correct configurations at all chiral centres. The later stages of the
Three new 10-phenyl-[11]cytochalasans, cytochalasins N, O, and P from Phomopsis sp.
Tomioka,Izawa,Koyama,Natori
, p. 902 - 905 (2007/10/02)
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