53777-78-9Relevant articles and documents
New synthetic method of 8-oxocoptisine starting from natural quaternary coptisine as anti-ulcerative colitis agent
Zhang, Zhi-Hui,Deng, An-Jun,Yu, Jin-Qian,Li, Zhi-Hong,Qin, Hai-Lin,Wu, Lian-Qiu,Zhang, Hai-Jing,Wang, Wen-Jie
, p. 841 - 846,6 (2014)
Quaternary coptisine (1), a natural bioactive quaternary protoberberine alkaloid (QPA), was treated with potassium ferricyanide in aqueous solution of 5 N sodium hydroxide leading to the acquisition of 8-oxocoptisine (2) with much higher yield than reported in the literature. This is the first report of the oxidation of a natural QPA by applying potassium ferricyanide as an oxidant. 8-Oxocoptisine showed significant anti-ulcerative colitis efficacy in vitro with EC50 value being 8.12 × 10-8 M.
