5378-17-6

Basic information

• Product Name: 1,2,4-Thiadiazol-3(2H)-one, 5-phenyl-
• CAS NO: 5378-17-6
• Molecular Formula: C8H6N2OS
• Molecular Weight: 178.214
• Mol File: 5378-17-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2,4-Thiadiazol-3(2H)-one, 5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Thiadiazol-3(2H)-one, 5-phenyl-(5378-17-6)
• EPA Substance Registry System: 1,2,4-Thiadiazol-3(2H)-one, 5-phenyl-(5378-17-6)

Safety Data

• Hazardous Substances Data: 5378-17-6(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

A heterocyclic compound is a cyclic compound that contains atoms of at least two different elements, in this case, carbon, nitrogen, sulfur, oxygen, and hydrogen.

Explanation

The compound contains a thiadiazole ring, which is a five-membered ring with two nitrogen atoms and one sulfur atom.

Explanation

The compound is used as a building block in organic synthesis, meaning it can be used to create more complex molecules by forming new chemical bonds.

Explanation

The compound is used in pharmaceutical research, which involves studying its properties and potential applications in the development of new drugs.

Explanation

The compound has been reported to have antiviral activity, meaning it can potentially inhibit the growth or replication of viruses.

Explanation

The compound has been reported to have antibacterial activity, meaning it can potentially inhibit the growth or reproduction of bacteria.

Explanation

The compound has been reported to have antifungal activity, meaning it can potentially inhibit the growth or reproduction of fungi.

Explanation

Due to its antiviral, antibacterial, and antifungal activities, the compound is potentially useful for the development of new drugs.

Explanation

The compound has been studied for its potential as a corrosion inhibitor, which means it could be used to protect materials from corrosion.

Explanation

The compound has been studied for its potential as a ligand in coordination chemistry, which involves the formation of complexes between metal ions and ligands.

Heterocyclic compound

Yes

Thiadiazole ring

Present

Building block in organic synthesis

Yes

Pharmaceutical research

Used in

Antiviral activity

Exhibits

Antibacterial activity

Exhibits

Antifungal activity

Exhibits

Potential drug development

Useful for

Corrosion inhibitor

Potential as

Coordination chemistry

Studied as a ligand

Upstream product

• 27182-54-3 5-phenyl-1,2,4-thiadiazol-3-amine 
• 5499-30-9 thiobenzoylurea 
• 1628-53-1 2-phenylthiazoline-4,5-dione 
• 7746-72-7 N¹-benzoyl-N³-cyanoguanidine 
• 89880-02-4 N-carbamoyl-N'-thiobenzoylguanidine 
• 4732-69-8 Chloro-oxo-acetic acid 
• 4648-54-8 trimethylsilylazide 
• 2227-79-4 benzenecarbothioamide 

Downstream Products

• 72183-12-1 3-acetoxy-5-phenyl-[1,2,4]thiadiazole 
• 106838-52-2 5-phenyl-3-(toluene-4-sulfonyloxy)-[1,2,4]thiadiazole 
• 7171-34-8 2-Phenyl-4-acetoamidothiazole 
• 46414-55-5 4-acetoxy-2-phenylthiazole 
• 72183-11-0 2-Acetyl-5-phenyl-1,2,4-thiadiazolin-3-one 
• 67488-19-1 N-Benzoyl-N,N'-dimethylharnstoff 
• 89879-85-6 2-methyl-5-phenyl-1,2,4-thiadiazol-3(2H)-one 
• 89879-87-8 4-methyl-5-phenyl-1,2,4-thiadiazolium-3-olate 
• 89879-86-7 3-methoxy-5-phenyl-1,2,4-thiadiazole 
• 61516-05-0 3-oxo-5-phenyl-3H-[1,2,4]thiadiazole-2-carboxylic acid methylamide 
• 3201-53-4 N-[(methylamino)carbonyl]benzamide 
• 89879-90-3 (Z)-2-(5-Phenyl-[1,2,4]thiadiazol-3-yloxy)-but-2-enedioic acid dimethyl ester 
• 89879-89-0 (E)-2-(5-Phenyl-[1,2,4]thiadiazol-3-yloxy)-but-2-enedioic acid dimethyl ester 

Relevant articles and documents

(Phenylalkylaminoalkyloxy)-heteroaryl-compounds, processes and intermediates for their production and pharmaceutical compositions containing them

3-(Phenylalkylaminoalkylozy)-heteroaryl compounds having heart rate lowering and/or anti-ischemic effects, methods for their preparation and pharmaceutical compositions containing them are described. The compounds correspond to the general formula I STR1 or to the general formula XXXI STR2 in which the substituents have the meanings given the specification.

Reactions of Trimethylsilyl Azide with Heterocumulenes

Trimethylsilyl azide (TMSA) reacted with aryl isocyanates to give arylcarbamoyl azides, 1-aryl-5(4H)-tetrazolinones, and / or 1-aryl-4-(arylcarbamoyl)-5(4H)-tetrazolinones, whose yields were dependent on the reaction conditions.The reaction between TMSA and benzoyl or thiobenzoyl isocyanates provides a facile method for the preparation of 5-aryl-3-hydroxy-1,2,4-oxadiazoles or -1,2,4-thiadiazoles, respectively.However, with phenyl or benzoyl isothiocyanate, 1-anilino-1,2,3,4-thiatriazole or benzoylcyanamide was obtained in low yield, respectively.TMSA reacted with carbodiimides to afford the corresponding 5-aminotetrazoles.Tetraphenylsuccinimide, N-(diphenylacetyl)tetraphenylsuccinimide, 1,3-bis(diphenylmethyl)urea, and / or benziloylamide were obtained from the reaction of TMSA with diphenyl ketene.The pathways for the formation of the above products are also described.