5382-18-3 Usage
General Description
4-Chloropiperidine is a chemical compound with the molecular formula C5H10ClN. It is a halogenated piperidine derivative that is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 4-Chloropiperidine is a colorless liquid with a pungent odor and is soluble in organic solvents such as ethanol and ether. It is considered to be a hazardous substance and should be handled with caution due to its potential health and environmental risks. 4-Chloropiperidine is primarily used in the production of medicines and as a building block for the synthesis of other organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 5382-18-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,8 and 2 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5382-18:
(6*5)+(5*3)+(4*8)+(3*2)+(2*1)+(1*8)=93
93 % 10 = 3
So 5382-18-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H10ClN/c6-5-1-3-7-4-2-5/h5,7H,1-4H2
5382-18-3Relevant articles and documents
Synthesis of 1-tert-butyl-4-chloropiperidine: Generation of an N-tert-butyl group by the reaction of a dimethyliminium salt with methylmagnesium chloride
Amato, Joseph S.,Chung, John Y. L.,Cvetovich, Raymond J.,Gong, Xiaoyi,McLaughlin, Mark,Reamer, Robert A.
, p. 1930 - 1933 (2007/10/03)
(Chemical Equation Presented) Two efficient routes to 1-tert-butyl-4- chloropiperidine are described. In the first route, the key thionyl chloride mediated chlorination reaction features the use of tetrabutyl-ammonium chloride as an additive that effectively suppresses the formation of an elimination-derived side product. In the second route, a novel alternative synthesis of 1-tert-butyl-4-chloropiperidine was developed in which the tertiary butyl group on the nitrogen is efficiently generated through the addition of methylmagnesium chloride to a dimethyliminium salt in 71% overall yield.
