538351-20-1Relevant articles and documents
An enantioselective synthesis of FR182877 provides a chemical rationalization of its structure and affords multigram quantities of its direct precursor
Vanderwal, Christopher D.,Vosburg, David A.,Weiler, Sven,Sorensen, Erik J.
, p. 5393 - 5407 (2003)
The evolution of a strategy culminating in an efficient, enantioselective synthesis of the potent microtubule-stabilizing agent FR182877 is described. Guided by a proposed biogenesis of this complex natural product, a solution emerged that involved the fi