53840-29-2

Basic information

• Product Name: ethyl 4-chloro-2,2-dimethylbutanoate
• Synonyms: ethyl 4-chloro-2,2-dimethylbutanoate
• CAS NO: 53840-29-2
• Molecular Formula: C8H15ClO2
• Molecular Weight: 178.6565
• Mol File: 53840-29-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 4-chloro-2,2-dimethylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-chloro-2,2-dimethylbutanoate(53840-29-2)
• EPA Substance Registry System: ethyl 4-chloro-2,2-dimethylbutanoate(53840-29-2)

Safety Data

• Hazardous Substances Data: 53840-29-2(Hazardous Substances Data)

Upstream product

• 107-04-0 1-Bromo-2-chloroethane 
• 97-62-1 Ethyl isobutyrate 
• 3709-08-8 3,3'-dimethylbutyrolactone 
• 64-17-5 ethanol 

Downstream Products

• 1431139-40-0 p-tolyl 2-O-(2,2-dimethyl-4-azidobutanoyl)-3,4-di-O-benzyl-1-thio-α-L-rhamnopyranoside 
• 1431139-38-6 p-tolyl 2-O-(2,2-dimethyl-4-azidobutanoyl)-3,4,6-tri-O-benzyl-1-thio-β-D-glucopyranoside 

Relevant articles and documents

Divergent Total Syntheses of Yaequinolone-Related Natural Products by Late-Stage C-H Olefination

Divergent total syntheses of 10 yaequinolone-related natural products have been achieved for the first time by late-stage C-H olefination of 3,4-dioxygenated 4-aryl-5-hydroxyquinolin-2(1H)-ones, core structures of this family of natural products. A robust synthetic methodology to construct the core structures has been established, and the C-H olefination reaction has been carried out with synthetically useful yields and high levels of site-selectivity under mild reaction conditions in the presence of a Pd/S,O-ligand catalyst.

IMPROVED CONJUGATION LINKERS

Provided are β-eliminative linkers suitable for the conjugation of small molecule, peptide, and protein and compounds comprising the linkers.

An oxidative approach to a hydroxypiperidinone utilizing a Rh-catalyzed C-H activation process

C-H activation and isomerization using a Rh-catalyst provided quick access to dehydropiperidine derivatives that could be further oxidized to hydroxypiperidinone derivatives.