53876-82-7

Basic information

• Product Name: C₁₇H₁₈O₄S₂
• CAS NO: 53876-82-7
• Molecular Weight: 350.46
• Mol File: 53876-82-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₈O₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₈O₄S₂(53876-82-7)
• EPA Substance Registry System: C₁₇H₁₈O₄S₂(53876-82-7)

Safety Data

• Hazardous Substances Data: 53876-82-7(Hazardous Substances Data)

Upstream product

• 108-98-5 thiophenol 
• 3406-02-8 bis(phenylsulfonyl)methane 
• 78-84-2 isobutyraldehyde 

Downstream Products

• 53876-80-5 C₁₇H₂₀O₄S₂ 

Relevant articles and documents

Syntheses a l'aide de sulfones. XVIII. Utilisation des disulfones-1,1 pour la synthese stereoselective de composes olefiniques

2-Alkenyl-1,1-disulfones 4 are readily available in excellent yields by condensation of aldehydes with bisaryl or bisalkylsulfonylmethanes in the presence of piperidine acetate and molecular sieves at room temperature.A small amount of the 1-alkenyl isomer is also found when the aldehyde is α-substituted but it can be converted into the 2-alkenyl isomer by base catalysed equilibration.The 2-alkenyl-1,1-disulfones display only E geometry whereas E allylic monosulfones are difficult to isolate in a state of stereochemical purity (about 20percent of the Z isomer at equilibrium (8)).Alkylation is readily performed: treatment of 4 and 6 by sodium hydride in dimethylformamide and then by methyl iodide gives disulfones 5 E and 7 in 78-95percent yields.The alkylation of 4 (R=Et) by butyl iodide gives 70percent of 5 E(R=Et, R'=n-Bu) resulting from alkylation at the α position and 8percent of 3 (R=Et, R'=n-Bu) resulting from alkylation at the γ position.The α isomer is readily purified by crystallization.Reduction of disulfones 4 or 5 by aluminium amalgam leads quantitatively to allylic sulfones 2E or 8E.Olefins 9E are obtained upon total reduction of disulfones 4 or 5 by lithium in ethylamine at -78 deg C but in the case of disulfones 5 the olefins 9E are contaminated by isomers 10E and 10Z.