53884-34-7

Basic information

• Product Name: bis(4-methoxy-3,5-dimethylphenyl)amine
• Synonyms: bis(4-methoxy-3,5-dimethylphenyl)amine
• CAS NO: 53884-34-7
• Molecular Weight: 285.386
• Mol File: 53884-34-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: bis(4-methoxy-3,5-dimethylphenyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: bis(4-methoxy-3,5-dimethylphenyl)amine(53884-34-7)
• EPA Substance Registry System: bis(4-methoxy-3,5-dimethylphenyl)amine(53884-34-7)

Safety Data

• Hazardous Substances Data: 53884-34-7(Hazardous Substances Data)

Upstream product

• 14804-39-8 2,6-dimethyl-4-nitroanisole 
• 14804-38-7 5-bromo-2-methoxy-1,3-dimethylbenzene 

Relevant articles and documents

Practical Singly and Doubly Electrophilic Aminating Agents: A New, More Sustainable Platform for Carbon-Nitrogen Bond Formation

Given the importance of amines in a large number of biologically active natural products, active pharmaceutical ingredients, agrochemicals, and functional materials, the development of efficient C-N bond-forming methods with wide substrate scope continues to be at the frontier of research in synthetic organic chemistry. Here, we present a general and fundamentally new synthetic approach for the direct, transition-metal-free preparation of symmetrical and unsymmetrical diaryl-, arylalkyl-, and dialkylamines that relies on the facile single or double addition of readily available C-nucleophiles to the nitrogen atom of bench-stable electrophilic aminating agents. Practical single and double polarity reversal (i.e., umpolung) of the nitrogen atom is achieved using sterically and electronically tunable ketomalonate-derived imines and oximes. Overall, this novel approach represents an operationally simple, scalable, and environmentally friendly alternative to transition-metal-catalyzed C-N cross-coupling methods that are currently used to access structurally diverse secondary amines.