5392-10-9Relevant articles and documents
Copolymerization of an indazole ligand into the self-polymerization of dopamine for enhanced binding with metal ions
Fan, Ka Wai,Roberts, Justine J.,Martens, Penny J.,Stenzel, Martina H.,Granville, Anthony M.
, p. 7457 - 7465 (2015)
5,6-Dihydroxy-1H-indazole (DHI) is able to self-polymerize through the same mussel-inspired chemistry responsible for generating poly(dopamine) (PDA), demonstrating the potential to expand this class of catecholamine-exclusive chemistry onto heterocyclic catechol derivatives for the preparation of functional materials. Although DHI exhibits slower polymerization kinetics compared to dopamine, the two chemical species are compatibly polymerizable under the same reaction conditions and allow the preparation of copolymer coatings in different molar ratios. Of these copolymers, the 1:3-copolymer (DHI-to-dopamine ratio) has demonstrated adequate structural stability as a polymer coating. While PDA performs as an intact framework, the incorporated DHI enhances the colloidal stability and provides additional coordinating functionality through the pyrazole moieties. The 1:3-copolymer was fabricated into polymer capsules which exhibit negligible cytotoxicity towards murine dermal fibroblasts (L929) and enhanced binding behaviour towards copper(ii). This represents a new channel for fabricating cargo carriers for biomedical applications that involve the use of transition metal-based species.
Diphyllin and application thereof in preparation of medicine for preventing or treating diabetes mellitus
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Paragraph 0029-0031, (2020/06/05)
The invention belongs to the technical field of medicine, and particularly relates to diphyllin represented by a formula I and an application of the diphyllin in preparation of medicine for preventingor treating diabetes mellitus, and experiments prove that the compound can improve insulin sensitivity of mice and reduce blood sugar. The compound is expected to be developed into a medicine for preventing or treating diabetes.
COMPOUNDS FOR THE INHIBITION OF UNREGULATED CELL GROWTH
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Page/Page column 34, (2020/07/14)
The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly cancer stem cells. Particularly, the invention relates to compounds of Formula I to XXII for the treatment of cancer.