53939-30-3 Usage
Description
5-Bromo-2-chloropyridine is an organic compound with the molecular formula C5H3BrClN. It is a light yellow crystalline substance that belongs to the pyridine family of heteroaromatic compounds. 5-Bromo-2-chloropyridine is characterized by the presence of a bromine atom at the 5th position and a chlorine atom at the 2nd position on the pyridine ring.
Uses
Used in Pharmaceutical Industry:
5-Bromo-2-chloropyridine is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a versatile building block in the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
5-Bromo-2-chloropyridine is used as a key intermediate in the preparation of several chemical compounds, such as:
1. Amino-2-chloropyridine: 5-Bromo-2-chloropyridine is synthesized via a palladium-catalyzed amination reaction, which can be further utilized in the development of various pharmaceuticals and agrochemicals.
2. 5-Bromo-2-fluoropyridine: 5-Bromo-2-chloropyridine is obtained through a halogen-exchange reaction using anhydrous potassium fluoride. It can be used as a starting material for the synthesis of other pyridine-based compounds with potential applications in various industries.
3. 2-Chloro-5-(2,5-dimethoxyphenyl)pyridine: 5-Bromo-2-chloropyridine is synthesized via a Suzuki coupling reaction with 2,5-dimethoxyphenylboronic acid. It can be used as a precursor for the development of novel compounds with potential applications in the pharmaceutical, agrochemical, and materials science industries.
Check Digit Verification of cas no
The CAS Registry Mumber 53939-30-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,3 and 9 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 53939-30:
(7*5)+(6*3)+(5*9)+(4*3)+(3*9)+(2*3)+(1*0)=143
143 % 10 = 3
So 53939-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H3BrClN/c6-4-1-2-5(7)8-3-4/h1-3H
53939-30-3Relevant articles and documents
Site-Selectivity in the Reaction of 3-Substituted Pyridine 1-Oxides with Phosphoryl Chloride
Yamanaka, Hiroshi,Araki, Tomio,Sakamoto, Takao
, p. 2244 - 2247 (2007/10/02)
Site-selectivity in the reaction of 3-substituted pyridine 1-oxide with phosphoryl chloride was investigated.When a strongly electron-withdrawing group (e.g.CN, CONRR', COOR, or NO2) was substituted at the 3-position, the reaction of 3-substituted pyridine 1-oxides with phosphoryl chloride yielded 3-substituted 2-chloropyridines as the main products.Keywords- site-selectivity; 3-substituted pyridine 1-oxide; phosphoryl chloride; 3-substituted 2-chloropyridine; chlorination
