53942-45-3 Usage
Description
O-3,4,6-Tri-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1-4)-O-3,6-di-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1-4)-2-(acetylamino)-2-deoxy-1,3,6-triacetate-a-D-glucopyranose is a complex organic compound with a unique chemical structure. It is characterized by its multiple acetylamino and acetyl groups, as well as its deoxy-glucopyranose units. O-3,4,6-Tri-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1-4)-O-3,6-di-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1-4)-2-(acetylamino)-2-deoxy-1,3,6-triacetate-a-D-glucopyranose is likely to have specific applications in various fields due to its unique properties.
Uses
1. Used in Pharmaceutical Industry:
O-3,4,6-Tri-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1-4)-O-3,6-di-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1-4)-2-(acetylamino)-2-deoxy-1,3,6-triacetate-a-D-glucopyranose is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential applications in treating various diseases.
2. Used in Chemical Research:
O-3,4,6-Tri-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1-4)-O-3,6-di-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1-4)-2-(acetylamino)-2-deoxy-1,3,6-triacetate-a-D-glucopyranose serves as a valuable research tool in the field of organic chemistry. It can be used to study the properties and reactivity of complex carbohydrates and their derivatives, contributing to the advancement of knowledge in this area.
3. Used in Synthesis of Chitosan Derivatives:
O-3,4,6-Tri-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1-4)-O-3,6-di-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1-4)-2-(acetylamino)-2-deoxy-1,3,6-triacetate-a-D-glucopyranose is used as an intermediate in the synthesis of chitosan derivatives, such as 4-Methylumbelliferyl β-D-N,N',N"-Triacetylchitotrioside. These derivatives have potential applications in various fields, including pharmaceuticals, agriculture, and environmental science.
4. Used in Diagnostic Applications:
As an intermediate in the synthesis of 4-Methylumbelliferyl β-D-N,N',N"-Triacetylchitotrioside, this compound can be utilized in the development of diagnostic tools for detecting specific enzymes, such as chitinases, which are important in various biological processes and disease states.
Check Digit Verification of cas no
The CAS Registry Mumber 53942-45-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,4 and 2 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 53942-45:
(7*5)+(6*3)+(5*9)+(4*4)+(3*2)+(2*4)+(1*5)=133
133 % 10 = 3
So 53942-45-3 is a valid CAS Registry Number.
InChI:InChI=1/C40H57N3O24/c1-15(44)41-29-36(60-23(9)52)33(27(13-56-19(5)48)63-38(29)62-25(11)54)66-40-31(43-17(3)46)37(61-24(10)53)34(28(65-40)14-57-20(6)49)67-39-30(42-16(2)45)35(59-22(8)51)32(58-21(7)50)26(64-39)12-55-18(4)47/h26-40H,12-14H2,1-11H3,(H,41,44)(H,42,45)(H,43,46)/t26?,27?,28?,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,40-/m0/s1
53942-45-3Relevant articles and documents
Acetylated chitosan oligosaccharides act as antagonists against glutamate-induced PC12 cell death via Bcl-2/Bax signal pathway
Hao, Cui,Gao, Lixia,Zhang, Yiran,Wang, Wei,Yu, Guangli,Guan, Huashi,Zhang, Lijuan,Li, Chunxia
, p. 1267 - 1289 (2015/04/14)
Chitosan oligosaccharides (COSs), depolymerized products of chitosan composed of β-(1→4) D-glucosamine units, have broad range of biological activities such as antitumour, antifungal, and antioxidant activities. In this study, peracetylated chitosan oligosaccharides (PACOs) and N-acetylated chitosan oligosaccharides (NACOs) were prepared from the COSs by chemcal modification. The structures of these monomers were identified using NMR and ESI-MS spectra. Their antagonist effects against glutamate-induced PC12 cell death were investigated. The results showed that pretreatment of PC12 cells with the PACOs markedly inhibited glutamate-induced cell death in a concentration-dependent manner. The PACOs were better glutamate antagonists compared to the COSs and the NACOs, suggesting the peracetylation is essential for the neuroprotective effects of chitosan oligosaccharides. In addition, the PACOs pretreatment significantly reduced lactate dehydrogenase release and reactive oxygen species production. It also attenuated the loss of mitochondrial membrane potential. Further studies indicated that the PACOs inhibited glutamate-induced cell death by preventing apoptosis through depressing the elevation of Bax/Bcl-2 ratio and caspase-3 activation. These results suggest that PACOs might be promising antagonists against glutamate-induced neural cell death.