53948-10-0

Basic information

• Product Name: Aristolactam BIII
• Synonyms: Aristolactam BIII
• CAS NO: 53948-10-0
• Molecular Formula: C18H15NO4
• Molecular Weight: 309.316
• Mol File: 53948-10-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Aristolactam BIII(CAS DataBase Reference)
• NIST Chemistry Reference: Aristolactam BIII(53948-10-0)
• EPA Substance Registry System: Aristolactam BIII(53948-10-0)

Safety Data

• Hazardous Substances Data: 53948-10-0(Hazardous Substances Data)

Usage

General Description

Aristolactam BIII is a chemical compound that belongs to the aristolactam alkaloids group, which are natural products found in plants such as Aristolochia and Asarum. It has been found to have potential toxic effects, particularly in relation to kidney damage and carcinogenicity. Aristolactam BIII has been studied for its potential role in causing renal fibrosis and urinary tract cancers, and has been associated with aristolochic acid nephropathy (AAN), a condition characterized by chronic kidney disease and an increased risk of developing urothelial malignancies. Due to its harmful effects, it is important to limit exposure to aristolactam BIII and other aristolactam alkaloids, particularly through the consumption of herbal products or traditional medicines that may contain these compounds.

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Relevant articles and documents

Synthesis of aristolactam analogues and evaluation of their antitumor activity

A series of natural aristolactams and their analogues have been prepared and evaluated for antitumor activity against human cancer cells, including multi-drug resistant cell lines. Naturally occurring aristolactams, such as aristolactam BII (cepharanone B

Total synthesis of aristolactams via a one-pot Suzuki-Miyaura coupling/aldol condensation cascade reaction

(Chemical Equation Presented) A direct one-pot synthesis of phenanthrene lactams, which employs a Suzuki -Miyaura coupling/aldol condensation cascade reaction of isoindolin-1-one with 2-formylphenylboronic acid, has been developed. The approach is used to

Intramolecular aryne cycloaddition approach to aristolactams

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