5396-98-5

Basic information

• Product Name: 2,3-DIPHENYL-1,4-DIAZASPIRO[4.5]DECA-1,3-DIENE
• Synonyms: 2,3-DIPHENYL-1,4-DIAZASPIRO[4.5]DECA-1,3-DIENE;1,4-Diazaspiro[4.5]deca-1,3-diene, 2,3-diphenyl-
• CAS NO: 5396-98-5
• Molecular Formula: C₂₀H₂₀N₂
• Molecular Weight: 288.39
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Imidazoles
• Mol File: 5396-98-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 106-108 °C(lit.)
• Boiling Point: 437.9°Cat760mmHg
• Flash Point: 211.3°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 1.85E-07mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: 2,3-DIPHENYL-1,4-DIAZASPIRO[4.5]DECA-1,3-DIENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIPHENYL-1,4-DIAZASPIRO[4.5]DECA-1,3-DIENE(5396-98-5)
• EPA Substance Registry System: 2,3-DIPHENYL-1,4-DIAZASPIRO[4.5]DECA-1,3-DIENE(5396-98-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 5396-98-5(Hazardous Substances Data)

Usage

General Description

2,3-Diphenyl-1,4-diazaspiro[4.5]deca-1,3-diene, also known as phenylpiracetam or carphedon, is a chemical compound that belongs to the class of nootropic drugs. It is derived from the parent compound piracetam and is known for its cognitive-enhancing and psychostimulant effects. Phenylpiracetam is thought to act as a positive allosteric modulator of the acetylcholine receptors in the brain, leading to improved memory, learning, and concentration. It has also been studied for its potential neuroprotective and antidepressant properties. 2,3-Diphenyl-1,4-diazaspiro[4.5]deca-1,3-diene is commonly used as a study aid and for increasing mental performance, but it is important to use this chemical with care and under the supervision of a healthcare professional due to potential side effects and interactions with other medications.

InChI:InChI=1/C20H20N2/c1-4-10-16(11-5-1)18-19(17-12-6-2-7-13-17)22-20(21-18)14-8-3-9-15-20/h1-2,4-7,10-13H,3,8-9,14-15H2

Upstream product

• 108-94-1 cyclohexanone 
• 134-81-6 benzil 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 501-65-5 diphenyl acetylene 
• 108-86-1 bromobenzene 

Downstream Products

• 29841-69-8 (S,S)-1,2-diphenyl-1,2-diaminoethane 
• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 
• 951-87-1 rac-1,2-diphenylethylene-1,2-diamine 
• 3190-04-3 (±)-2,3-diphenyl-1,4-diazaspiro[4.5]decane 

Relevant articles and documents

Diversity-Oriented Synthesis of a Library of Star-Shaped 2H-Imidazolines

A library of star-shaped 2H-imidazolines has been synthesized via Debus-Radziszewski condensation from 1,2-diketones and ketone starting materials. Selective reduction of one imine group of the 2H-imidazole intermediate with LiAlH4 or catalytic flow hydrogenation furnished 2H-imidazolines, which could be conveniently diversified by reacting the amine N with electrophiles, resulting in a set of 21 amide-, carbamate-, urea-, and allylamine-containing products. In total, five points of diversification could be used, which allow the production of a set of functionally diverse compounds. The synthesis of acylated 2H-imidazolidines resulted in intrinsically labile compounds, which spontaneously degraded to acyclic derivatives, as shown for the reaction of 2H-imidazolidine with hexylisocyanate.

Assisted tandem catalytic cross metathesis-oxidation: In one flask from styrenes to 1,2-diketones and further to quinoxalines

1,2-Diketones were synthesized from styrenes by combining a cross metathesis and a Ru-catalyzed alkene oxidation to an assisted tandem catalytic sequence. The synthesis relies on the use of just one metathesis precatalyst, which was in situ converted to the oxidation catalyst by addition of an alkyl hydroperoxide as a chemical trigger and oxidant. The one-flask sequence can be extended beyond 1,2-diketones to quinoxalines, by condensation of the oxidation products with ortho-phenylenediamine.

Comparison of Birch with electrochemical reduction of 2,3-diphenyl-1,4- diazaspiro[4.5]deca-1,3-diene

Reduction of 2,3-diphenyl-1,4-diazaspiro[4.5]deca-1,3-diene is investigated both voltammetrically (glassy-carbon electrode, 20 °C, non-aqueous- solvents) and using dissolving-metals (sodium, -78 °C, tetrahydrofuran (THF)/NH3(l)). Remarkably, el