54001-12-6Relevant articles and documents
Synthesis of novel thiazol-5-ylpyrimidine derivatives and their antimicrobial evaluation
Deshmukh, Sanjay U.,Toche, Raghunath B.,Takate, Sushama J.,Salve, Supriya P.,Sabnis, Ram W.
, p. 4070 - 4077 (2020)
Novel thiazol-5-ylpyrimidine derivatives were designed and synthesized. The chemical structures of all new synthesized compounds were assigned by studying their elemental analyses and spectral data (FT-IR, 1HNMR, 13C NMR, and MS). Th
Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity
Chen, Yazhen,Su, Fen,Wang, Peiyi,Zhu, Jianjun
, (2021/09/13)
A series of novel thiazolyl hydrazine derivatives 3a-3o were synthesized and evaluated for their in vitro antifungal activity against six phytopathogenic strains, namely, Botryosphaeria dothidea (B. d.), Gibberella sanbinetti (G. s.), Fusarium oxysporum (F. o.), Thanatephorus cucumeris (T. c.), Sclerotinia sclerotiorum (S. s.), and Verticillium dahliae (V. d.), by the classical mycelial growth rate method. Biological assessment results showed that most of these target compounds showed good antifungal activity toward tested strains. Especially, compound 3l showed excellent antifungal activities against B. d. and G. s. with relatively lower EC50 values of 0.59 and 0.69 μg/mL, respectively, which were extremely superior to those of commercial fungicides fluopyram, boscalid, and hymexazol and were comparable to those of carbendazim. Given the excellent bioactivity of designed compounds, this kind of thiazolyl hydrazine framework can provide a suitable point for exploring highly efficient antifungal agents.
Synthesis of novel (thiazol-5-yl)pyrazoles and their antimicrobial evaluation
Deshmukh, Sanjay U.,Sabnis, Ram W.,Salve, Supriya P.,Takate, Sushama J.,Toche, Raghunath B.
, p. 1785 - 1798 (2020/11/19)
A series of novel (thiazol-5-yl)pyrazoles were designed and synthesized. All the synthesized compounds were characterized by spectroscopic analysis and were evaluated for their antimicrobial activity in vitro against Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus, Gram-negative bacteria, Salmonella abony and Escherichia coli and fungi, Aspergillus flavus and Fusarium oxysporum.