54027-45-1

Basic information

• Product Name: N-(2,3-dimethylphenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(2,3-dimethylphenyl)-4-methylbenzenesulfonamide
• CAS NO: 54027-45-1
• Molecular Formula: C₁₅H₁₇NO₂S
• Molecular Weight: 275.36598
• Mol File: 54027-45-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2,3-dimethylphenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-dimethylphenyl)-4-methylbenzenesulfonamide(54027-45-1)
• EPA Substance Registry System: N-(2,3-dimethylphenyl)-4-methylbenzenesulfonamide(54027-45-1)

Safety Data

• Hazardous Substances Data: 54027-45-1(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 941-55-9 4-toluenesulfonyl azide 
• 95-47-6 o-xylene 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 87-59-2 2,3-Dimethylaniline 

Relevant articles and documents

Utilization of transition metal fluoride-based solid support catalysts for the synthesis of sulfonamides: Carbonic anhydrase inhibitory activity and: In silico study

The applications of solid support catalysts in catalyzing organic reactions are well-evident. In the present study, we explored a transition metal fluoride (FeF3) adsorbed on molecular sieves (4 ?) as a solid support catalyst for the preparation of sulfon

N-sulfonated derivatives of 2,3-xylidine as suitable antibacterial agents

The objective of the current research effort was to unravel the antibacterial potential of some newly synthesized sulfonamides. 2,3-Dimethylaniline (2,3-xylidine, 1) was reacted with different sulfonyl chlorides (2a-g) under dynamic control of pH (9-10) in aqueous alkaline medium to generate a series of N-sulfonated derivatives of 2,3-xylidine (3a-g). The plausible structures of the synthesized derivatives were corroborated by contemporary spectral techniques e.g. IR,1H-NMR and EIMS. Moreover, N-sulfonated derivatives were screened against different gram negative and positive bacterial strains to evaluate their inhibitory potential. They depicted good to moderate inhibitory potential, especially, N-(2,3-dimethylphenyl)methanesulfonamide (3a), N-(2,3- dimethylphenyl)-4-methylbenzenesulfonamide (3b), N-(2,3-dimethylphenyl)-4- bromobenzenesulfonamide (3d) and N-(2,3-dimethylphenyl)naphthalene-2-yl-sulfonamide (3f) were amongst the potent inhibitors as compared to standard; Ciprofloxacin.

Identification of novel glycine sulfonamide antagonists for the EP1 receptor

A high-throughput screen targeting the EP1 receptor identified non-acidic glycine sulfonamide derivative 2a with a pKi of 6.2. Analogue synthesis allowed a thorough investigation of the structure-activity relationship (SAR) and led to a 100-fold increase in recombinant potency.