540524-58-1

Basic information

• Product Name: methyl 4-({2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethyl}sulfonyl)benzoate
• Synonyms: methyl 4-({2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethyl}sulfonyl)benzoate
• CAS NO: 540524-58-1
• Molecular Weight: 775.774
• Mol File: 540524-58-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-({2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethyl}sulfonyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-({2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethyl}sulfonyl)benzoate(540524-58-1)
• EPA Substance Registry System: methyl 4-({2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethyl}sulfonyl)benzoate(540524-58-1)

Safety Data

• Hazardous Substances Data: 540524-58-1(Hazardous Substances Data)

Upstream product

• 540522-59-6 methyl 4-({2-[2-(2-aminoethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethyl}sulfonyl)benzoate 
• 77421-13-7 (2-chlorobenzyl)sulfonyl chloride 

Relevant articles and documents

Indole cytosolic phospholipase A2 α inhibitors: Discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4- dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl} benzoic acid, efipladib

The optimization of a class of indole cPLA2α inhibitors is described herein. The importance of the substituent at C3 and the substitution pattern of the phenylmethane sulfonamide region are highlighted. Optimization of these regions led to the