5407-84-1

Basic information

• Product Name: (1-phenylcyclopentyl)acetonitrile
• CAS NO: 5407-84-1
• Molecular Formula: C₁₃H₁₅N
• Molecular Weight: 185.2649
• Mol File: 5407-84-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 326.7°C at 760 mmHg
• Flash Point: 164.5°C
• Density: 1.016g/cm³
• Vapor Pressure: 0.000212mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: (1-phenylcyclopentyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (1-phenylcyclopentyl)acetonitrile(5407-84-1)
• EPA Substance Registry System: (1-phenylcyclopentyl)acetonitrile(5407-84-1)

Safety Data

• Hazardous Substances Data: 5407-84-1(Hazardous Substances Data)

Usage

Description

(1-phenylcyclopentyl)acetonitrile, with the molecular formula C12H13N, is a nitrile compound characterized by the presence of the CN functional group. It features a phenyl group and a cyclopentyl group attached to the acetonitrile moiety, endowing it with a unique structure that facilitates diverse chemical transformations. (1-phenylcyclopentyl)acetonitrile plays a significant role in the field of organic chemistry, particularly as an intermediate in the synthesis of pharmaceuticals and other organic compounds.

Uses

Used in Pharmaceutical Industry:
(1-phenylcyclopentyl)acetonitrile is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its versatile structure allows it to participate in multiple chemical reactions, contributing to the development of new drugs and therapeutic agents.
Used in Organic Chemistry Research:
As a compound with a distinct structure, (1-phenylcyclopentyl)acetonitrile serves as a valuable reagent in organic chemistry research. It is employed in various chemical transformations to explore new reaction pathways and synthesize novel organic compounds.
Used in Chemical Synthesis:
The presence of the acetonitrile group in (1-phenylcyclopentyl)acetonitrile makes it a versatile reagent for a wide range of chemical reactions. It is used in the synthesis of various organic compounds, including those with potential applications in materials science, agrochemicals, and other industries.

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 5407-83-0 ethyl 2-cyano-2-cyclopentylideneacetate 
• 100611-61-8 (1-phenyl-cyclopentyl)-acetaldehyde 
• 773837-37-9 sodium cyanide 
• 59115-90-1 1-hydroxymethyl-1-phenylcyclopentane 
• 21573-69-3 1-phenyl-1-cyclopentanecarboxaldehyde 
• 77-57-6 1-phenyl-1-cyclopentanecarbonitrile 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 1616924-72-1 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylmethylamide 
• 1616922-83-8 5-(benzyloxy)-6-hydroxy-2-((1-phenylcyclopentyl)methyl)pyrimidine-4-carboxylic acid 
• 1616922-81-6 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester 
• 1616922-79-2 2-(1-phenylcyclopentyl)acetamidine hydrochloride 
• 1616924-78-7 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](4-fluorobenzyl)amide 
• 1616924-76-5 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](tetrahydropyran-4-yl)amide 
• 1616924-69-6 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl](2,2-dimethylpropyl)amide 
• 1616924-66-3 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)oxetan-3-ylamide 
• 1616924-65-2 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]oxetan-3-ylamide 
• 1616924-61-8 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclobutylamide 
• 1616924-57-2 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopentylamide 
• 1616924-55-0 9-benzyloxy-2-cyclopropyl-6-(1-phenylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 1616924-54-9 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid cyclopropyl(2-hydroxyethyl)amide 
• 1616924-53-8 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylamide 

Relevant articles and documents

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease, in particular influenza.

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

Iridium-catalyzed ring cleavage reaction of cyclobutanone O-benzoyloximes providing nitriles

(Chemical Equation Presented) Iridium-catalyzed ring cleavage reaction of cyclobutanone O-benzoyloximes in the presence of 9,10-dihydroanthracene and potassium carbonate proceeds to give saturated nitriles via C-C bond fission at the sterically more hinde