5409-63-2

Basic information

• Product Name: 1-(biphenyl-4-yl)-3-(dimethylamino)propan-1-one
• CAS NO: 5409-63-2
• Molecular Formula: C₁₇H₁₉NO*ClH
• Molecular Weight: 253.3389
• Mol File: 5409-63-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 390.8°C at 760 mmHg
• Flash Point: 144.4°C
• Density: 1.042g/cm³
• Vapor Pressure: 2.58E-06mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 1-(biphenyl-4-yl)-3-(dimethylamino)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(biphenyl-4-yl)-3-(dimethylamino)propan-1-one(5409-63-2)
• EPA Substance Registry System: 1-(biphenyl-4-yl)-3-(dimethylamino)propan-1-one(5409-63-2)

Safety Data

• Hazardous Substances Data: 5409-63-2(Hazardous Substances Data)

Usage

Type of compound

Ketone

Structure

Biphenyl group attached to the first carbon
Dimethylamino group attached to the third carbon of the propyl chain

Field of application

Organic chemistry

Usage

Synthesis of various pharmaceuticals
Synthesis of organic compounds

Pharmacological properties

Potential use as a psychoactive substance

Hazard

Can be hazardous if not handled properly

Safety precaution

Use with caution

Upstream product

• 92-91-1 biphenyl-4-acetaldehyde 
• 506-59-2 N,N-dimethylammonium chloride 
• 50-00-0 formaldehyd 

Downstream Products

• 1425336-15-7 1-(biphenyl-4-yl)-3-(5,6-dimethyl-1H-benzimidazol-1-yl)-1-propanone 
• 1425336-12-4 1-(biphenyl-4-yl)-3-(2-methyl-1H-benzimidazol-1-yl)-1-propanone 
• 108664-43-3 1-[2-(Biphenyl-4-carbonyl)-allyl]-1H-pyridin-2-one 
• 108664-39-7 1-Biphenyl-4-yl-2-[1,2,4]triazol-1-ylmethyl-propenone 
• 108664-42-2 1-(4-phenylphenyl)-2-<(1H-pyrazol-1-yl)methyl>-2-propen-1-one 
• 35076-77-8 4-cyclopropyl-1,1'-biphenyl 

Relevant articles and documents

A novel antifungal agent with broad spectrum: 1-(4-Biphenylyl)-3-(1H- imidazol-1-yl)-1-propanone

A series of (1-substituted aryl)-3-(1H-imidazol-1-yl)-1-propanones was synthesized through the N-alkylation of imidazole with 3-dimethylamino-1- (substituted aryl)-1-propanone hydrochlorides (ketonic Mannich bases). A second series of N1-substituted imidazoles was obtained by the reduction of the carbonyl function of the imidazole-ketones in the previous series by means of NaBH4. All of the compounds were evaluated for antifungal activity against 16 strains of Candida, and 3-(1H-imidazol-1-yl)-1-(4-biphenylyl)-1- propanone emerged as a broad-spectrum antifungal agent. Several 3-(1H-imidazol-1-yl)-1-(2′-(substituted benzyl)oxyphenyl)-1-propanones were also active towards Candida kefyr. Copyright

Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones

To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '