54092-73-8 Usage
Description
Chrysene, 1,2,3,4-tetrahydro-11-methylis a chemical compound derived from chrysene, a polycyclic aromatic hydrocarbon (PAH). It is characterized by its unique molecular structure, where four of the carbon-carbon double bonds are hydrogenated, and an additional methyl group is attached at the 11th position. Chrysene, 1,2,3,4-tetrahydro-11-methylis known for its potential role in the synthesis of other chemical compounds and its interaction with biological receptors.
Uses
Used in Chemical Synthesis:
Chrysene, 1,2,3,4-tetrahydro-11-methylis used as an intermediate in the synthesis of 5-Methylchrysene (M265135), a methylated derivative of chrysenes (MeChry). This derivative is an aryl hydrocarbon receptor (AhR) agonist, which means it can bind to and activate the AhR, a protein that plays a role in various biological processes.
Used in Pharmaceutical Research:
As an AhR agonist, 1,2,3,4-tetrahydro-11-methylchrysene and its derivatives may have potential applications in the development of pharmaceuticals targeting the aryl hydrocarbon receptor. This receptor is involved in the regulation of gene expression, cell differentiation, and immune responses, making it a promising target for drug development in various therapeutic areas.
Used in Environmental and Toxicological Studies:
Due to its structural similarity to other PAHs, 1,2,3,4-tetrahydro-11-methylchrysene may also be used in environmental and toxicological research to better understand the effects of PAH exposure on human health and the environment. This knowledge can contribute to the development of strategies for mitigating the risks associated with PAH exposure.
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 3885, 1988 DOI: 10.1016/S0040-4039(00)80371-8
Check Digit Verification of cas no
The CAS Registry Mumber 54092-73-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,0,9 and 2 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 54092-73:
(7*5)+(6*4)+(5*0)+(4*9)+(3*2)+(2*7)+(1*3)=118
118 % 10 = 8
So 54092-73-8 is a valid CAS Registry Number.
54092-73-8Relevant articles and documents
α-Oxoketene dithioacetal mediated aromatic annulation: Highly efficient and concise synthetic routes to potentially carcinogenic polycyclic aromatic hydrocarbons
Nandi, Sukumar,Panda, Kausik,Suresh,Ila, Hiriyakkanavar,Junjappa, Hiriyakkanavar
, p. 3663 - 3673 (2007/10/03)
Highly efficient regiospecific routes to potentially carcinogenic polycyclic aromatic hydrocarbons such as substituted benzo[c]phenanthrenes, benzo[c]fluorenes, 16,17-dihydro-11-methyl-15[H]cyclopenta[a]phenanthrene, 5-methyl-7,8,9,10-tetrahydrochrysene and 1,4-dimethylphenanthrene have been developed. The overall strategy involves our aromatic annulation protocol through base induced conjugate addition-elimination on the cyclic and acyclic α-oxoketene dithioacetals with the appropriate arylacetonitriles followed by acid induced cyclodehydration of the resulting conjugate adducts. Subsequent reductive dethiomethylation (Raney Ni) and dehydrogenation (DDQ) of the cyclized products affords the methyl substituted PAHs in high yields.
