541-50-4Relevant articles and documents
Lehninger,Greville
, (1953)
Kinetic study of the neutral and base hydrolysis of diketene
Goemez-Bombarelli, Rafael,Gonzalez-Perez, Marina,Perez-Prior, Maria Teresa,Manso, Jose A.,Calle, Emilio,Casado, Julio
, p. 438 - 442 (2009)
Diketene (4-methylene-2-oxetanone) is inactive as a carcinogen, although it is more reactive toward nucleophiles than the analogs b-propiolactone and b-butyrolactone, both of which are alkylating agents of known carcinogenicity. In the literature the lack of carcinogenic effects has been ascribed to the rapid hydrolysis of diketene, which could preclude its in vivo alkylating capacity. In this work, the kinetics of the neutral and alkaline hydrolysis of diketene in aqueous and different water-dioxane media have been studied. The following conclusions can be drawn: (i) The neutral hydrolysis of diketene is slightly faster than that of β-propiolactone and β-butyrolactone. (ii) The hydrolysis reaction of diketene is very slow when compared to its alkylation reaction of a DNA-model carcinogenicity. (iii) The diketene neutral hydrolysis rate constant increases with the water/dioxane ratio, the opposite occurring in base hydrolysis. Copyright
Hsiang et al.
, p. 2098 (1972)
Discrepancies in the reactivity pattern of azaenamines towards cinnamonitriles: Synthesis of novel aza-steroid analogues
Ghozlan, Said A.S.,Abdelmoniem, Amr M.,Butensch?n, Holger,Abdelhamid, Ismail A.
, p. 1413 - 1418 (2015)
Azaenamine incorporating pyrazole-4-carboxylate is prepared and allowed to react with α,β-substituted nitriles. A new reactivity pattern was observed leading to the formation of substituted pyrazolo[4′,3′-5,6]pyrimido[2,1-a]phthalazine-9-carbonitriles, which can be considered as aromatic aza-steroid analogues.
3,4-DIHYDROXYPHENETHYL 3-HYDROXYBUTANOATE, PREPARATION AND USE THEREOF
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Paragraph 0108, (2021/03/19)
The present disclosure discloses a novel compound, 3,4-dihydroxyphenethyl 3-hydroxybutanoate, a method for preparing the same and use of the same, and in particular, a compound of formula I, use of the compound of formula I, optically pure isomers of the compound, a mixture of enantiomers in any ratio, or pharmaceutically acceptable salts thereof in preparing health food and drug for relieving brain fatigue, improving learning and memory abilities, and ameliorating mania mood related to brain fatigue.
MULTIBIOTIC AGENTS AND METHODS OF USING THE SAME
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Page/Page column 84; 85, (2019/01/06)
Multibiotic agents are disclosed. The multibiotic agents may contain two or more moieties linked through bonds cleavable in vivo. The bonds cleavable in vivo can be ester bonds, amide bonds, azo bonds, glycosidic bonds, carbonate linkers, or carbamate linkers. The moieties can be alcohol cores, amine cores, and/or acyls. Also disclosed are compositions containing multibiotic agents and methods of using the multibiotic agents.