54108-26-8

Basic information

• Product Name: ethyl 2,3-dihydro-5,6-diphenyl-3-oxopyridazine-4-carboxylate
• Synonyms: ethyl 2,3-dihydro-5,6-diphenyl-3-oxopyridazine-4-carboxylate
• CAS NO: 54108-26-8
• Molecular Weight: 320.348
• Mol File: 54108-26-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2,3-dihydro-5,6-diphenyl-3-oxopyridazine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,3-dihydro-5,6-diphenyl-3-oxopyridazine-4-carboxylate(54108-26-8)
• EPA Substance Registry System: ethyl 2,3-dihydro-5,6-diphenyl-3-oxopyridazine-4-carboxylate(54108-26-8)

Safety Data

• Hazardous Substances Data: 54108-26-8(Hazardous Substances Data)

Upstream product

• 134-81-6 benzil 
• 5344-88-7 benzil monohydrazone 
• 105-53-3 diethyl malonate 

Downstream Products

• 112450-33-6 ethyl 3-mercapto-5,6-diphenylpyridazine-4-carboxylate 
• 248935-66-2 (+/-)-5-carbethoxy-3,4-diphenyl-1-(2,3-O-isopropylidene-2,3-dihydroxyprop-1-yl)-1H-pyridazin-6-one 
• 111221-51-3 ethyl 5,6-diphenyl-N(2)-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-pyridazin-3-one-4-carboxylate 
• 101716-86-3 2-methyl-3-oxo-5,6-diphenyl-2,3-dihydro-pyridazine-4-carboxylic acid 
• 101444-26-2 5,6-Diphenyl-2-methylpyridazin-3-one 
• 2166-34-9 5,6-diphenylpyridazine-3-(2H)-one 
• 112450-29-0 2,3-dihydro-5,6-diphenyl-3-thio-pyridazin-4-yl-diphenyl-thiocarbinol 

Relevant articles and documents

Synthesis, in-vitro evaluation, molecular docking, and kinetic studies of pyridazine-triazole hybrid system as novel α-glucosidase inhibitors

In this study, we reported the discovery of pyridazine based 1,2,3-triazole derivatives as inhibitors of α-glucosidase. All target compounds exhibited significant inhibitory activities against yeast and rat α-glucosidase enzymes compared to positive control, acarbose. The most potent compound 6j, ethyl 3-(2-(1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)ethyl)-5,6-diphenylpyridazine-4-carboxylate exhibited IC50 values of 58, and 73 μM. Docking studies indicated the responsibility of hydrophobic and hydrogen bonding interactions in the ligand-enzyme complex stability. The in-vitro safety against the normal cell line was observed by toxicity evaluation of the selected compounds.